Usual starting dose of regorafenib? For a 75 yo pt?Usual starting dose of regorafenib? For a 75 yo pt?In general, what is the usual starting dose of regorafenib that you use? What is the starting dose that you use for a 75-year-old patient? Davis SL et al. The development of regorafenib and its current and potential future role in cancer therapy. Drugs Today (Barc) 2013;49(2):105-15. Abstract Mross K et al. A phase I dose-escalation study of regorafenib (BAY 73-4506), an inhibitor of oncogenic, angiogenic, and stromal kinases, in patients with advanced solid tumors. Clin Cancer Res 2012;18(9):2658-67. Abstract Shahda S, Saif MW. Regorafenib: From bench to bedside in colorectal cancer. Expert Rev Clin Pharmacol 2013;6(3):243-8. Abstract Strumberg D et al. Regorafenib (BAY 73-4506) in advanced colorectal cancer: A phase I study. Br J Cancer 2012;106(11):1722-7. Abstract Van Cutsem E et al. Regorafenib (REG) in progressive metastatic colorectal cancer (mCRC): Analysis of age subgroups in the phase III CORRECT trial. Proc ASCO 2013;Abstract 3636. |