Recent Advances in Cancer Care — New Paradigms, Novel Agents and What It Means for the Oncology Nurse: Strategies to Safely and Effectively Implement Antibody-Drug Conjugates

A Complimentary NCPD Symposium Held During the 51st Annual ONS Congress

Program Schedule — Central Time

10:45 AM – 11:15 AM — Registration and Lunch
11:15 AM – 12:45 PM — Educational Meeting

Location

San Antonio Marriott Rivercenter
101 Bowie St
San Antonio, Texas
Hotel Phone: (210) 223-1000

Meeting Room

Grand Ballroom A-F (Third Floor)

No registration fee is charged for this event. For the in-person symposium in San Antonio, preregistration is required as seating is limited.

Faculty

Courtney Arn

Faculty

Courtney Arn

CNP

The Ohio State University, Columbus, Ohio

The James Cancer Hospital and Solove Research Institute

Jamie Carroll

Faculty

Jamie Carroll

APRN, MSN, CNP

Mayo Clinic, Rochester, Minnesota

Assistant Professor, Oncology

Edward B Garon

Faculty

Edward B Garon

MD, MS

David Geffen School of Medicine at UCLA, Jonsson Comprehensive Cancer Center, Los Angeles, California

Professor, Director, Thoracic Oncology Program, Director, Signal Transduction and Therapeutics Research Program

Heather McArthur

Faculty

Heather McArthur

MD, MPH, FASCO

UT Southwestern Medical Center, Dallas, Texas

Professor, Department of Internal Medicine, Clinical Director, Breast Cancer Program, Komen Distinguished Chair in Clinical Breast Cancer Research

Kathleen N Moore

Moderator

Kathleen N Moore

MD, MS

Fred and Pamela Buffett Cancer Center at the University of Nebraska, Omaha, Nebraska

Deputy Director and Director, Phase 1 Clinical Trials

Meeting space has been assigned to provide a symposium supported by AstraZeneca Pharmaceuticals LP, Daiichi Sankyo Inc, and Merck during the Oncology Nursing Society’s (ONS) 51st Annual Congress, May 13-17, 2026 in San Antonio, TX. The Oncology Nursing Society’s assignment of meeting space does not imply product endorsement.

    Program Schedule — Central Time

    10:45 AM – 11:15 PM — Registration and Lunch
    11:15 AM – 12:45 PM — Educational Meeting

    MODULE 1: Rationale for the Use of Antibody-Drug Conjugates (ADCs) as Cancer Treatment

    • Rationale for conjugating monoclonal antibodies with cytotoxic drugs to form ADCs; theoretical improvement of chemotherapy efficacy while reducing systemic exposure and toxicity
    • Structural components, such as antibodies, linkers and cytotoxic payloads, of commercially available and investigational ADCs
    • Direct mechanism of antitumor activity of ADCs and other means by which they can elicit an antitumor effect, such as bystander killing

    MODULE 2: Current and Future Role of ADCs in Cancer Therapy

    • FDA-approved indications for ADCs in various tumor types
    • Clinical significance of FDA breakthrough therapy designation and current ADCs in development receiving this distinction
    • Biological rationale for combining ADCs with other cancer therapies (eg, immune checkpoint inhibitors) and current and future role of this strategy in treatment
    • Emerging findings with and ongoing studies evaluating ADCs for patients with non-metastatic disease
    • Other promising investigational ADCs in clinical development

    MODULE 3: Practical Considerations with ADCs

    • Setting patient expectations regarding ADC efficacy and tolerability
    • Optimal timing for initiation of approved ADCs or consideration of a clinical trial evaluating 1 of these agents
    • ADC effectiveness for patients with CNS metastases
    • Mechanisms of resistance to ADCs; feasibility of using multiple agents in this class sequentially for the same patient

    MODULE 4: Cytopenias Associated with ADCs

    • Educating patients regarding the capacity of ADCs to cause acute “chemotherapy-like” side effects
    • Incidence and severity of neutropenia, thrombocytopenia and anemia with approved and investigational ADCs
    • Indications for prophylactic growth factor use for patients who are about to start treatment with an ADC
    • Appropriate monitoring of complete blood counts during ADC therapy; thresholds for dose modification, treatment interruption and treatment discontinuation for patients experiencing cytopenias

    MODULE 5: Gastrointestinal (GI) Adverse Events (AEs) Documented with ADCs

    • Rates of various GI issues (eg, nausea, vomiting, diarrhea, constipation, abdominal pain) in patients receiving ADC therapy
    • Indications for prophylactic antiemetics and antidiarrheals for patients who are about to start treatment with an ADC
    • Role of nutritional counselling and diet modifications during ADC treatment
    • Potential advantages of complementary therapies, such as acupuncture and yoga, in managing GI side effects of ADCs

    MODULE 6: Recognition and Management of Interstitial Lung Disease (ILD)/Pneumonitis Associated with ADCs

    • Pathophysiology of ILD/pneumonitis associated with ADCs; baseline risk factors for its development
    • Rates, severity and timing of ILD/pneumonitis in clinical trial experiences with various ADCs
    • Appropriate workup for patients suspected of experiencing therapy-related ILD/pneumonitis; strategies to distinguish drug-related pulmonary toxicity from other potential causes
    • Guidelines for treatment modifications and discontinuation for patients experiencing ILD/pneumonitis; indications for restarting ADC therapy after resolution
    • Utility of other supportive care measures, such as corticosteroids and oxygen supplementation, for patients experiencing ILD/pneumonitis

    MODULE 7: Potential for Mucositis/Stomatitis with ADCs

    • Incidence and severity of mucositis/stomatitis with various approved and investigational ADCs
    • Counseling patients on the importance of oral hygiene during treatment with ADCs known to cause mucositis/stomatitis
    • Role of steroid mouthwash, prophylactic antibiotics/antifungals and pain medications for patients who are at risk for or are experiencing mucositis/stomatitis
    • Dietary recommendations for patients experiencing mucositis/stomatitis

    MODULE 8: Ocular Toxicities with ADCs

    • Pathophysiology of ocular AEs associated with certain ADCs; spectrum, incidence and severity of ocular toxicities with different agents
    • Optimal patient counseling and education regarding signs of ocular toxicity and the importance of early reporting of symptoms
    • Utility of other prophylactic and supportive care measures to mitigate and manage ocular toxicities
    • Importance of interdisciplinary coordination with eye-care professionals in the identification and management of treatment-related ocular AEs

    MODULE 9: Cardiovascular AEs Associated with Select ADCs

    • Pathophysiology of the cardiotoxicity associated with anti-HER2 therapies, including ADCs
    • Incidence of left ventricular dysfunction noted with HER2-targeted ADCs in clinical trial experiences
    • Appropriate monitoring of left ventricular ejection fraction (LVEF) at baseline and during treatment with HER2-targeted ADCs
    • Threshold for treatment interruption for patients experiencing LVEF decrease; indications for restarting HER2-targeted ADC therapy after recovery
    • Role of interdisciplinary coordination with cardiologists when monitoring for and managing cardiac toxicities associated with HER2-targeted ADCs

    MODULE 10: Other Toxicities Reported with 1 or More ADCs

    • Incidence and management of peripheral neuropathy associated with various ADCs
    • Rates of alopecia reported with ADC treatment; available strategies to reduce the incidence/severity of hair loss or limit its psychosocial impact (eg, scalp-cooling methods, wigs/hair pieces)
    • Available strategies to ameliorate the symptoms of rash and other cutaneous reactions associated with ADCs (eg, antihistamines, topical steroids, emollients)
    • Spectrum of other toxicities (eg, fatigue, hemorrhage, effusion/edema, hyperglycemia) associated with 1 or more ADCs used in the treatment of cancer

    Target Audience
    This activity has been designed to meet the educational needs of oncology nurses, nurse practitioners and clinical nurse specialists involved in the treatment of cancer.

    Learning Objectives
    Upon completion of this activity, participants should be able to

    • Consider the scientific justification for antibody-drug conjugates (ADCs) as a therapeutic approach for patients with various tumor types, and recall the differential targets, structural components and mechanisms of activity of different clinically available and investigational ADCs.
    • Appraise available clinical research data with novel ADCs for various cancers, and consider the current and potential role of these approaches in routine clinical care.
    • Appreciate the pathophysiology and severity of common and rare toxicities associated with ADCs employed in the treatment of different tumor types.
    • Understand the incidence of toxicities observed in pivotal trials evaluating novel ADCs demonstrating efficacy in the management of various tumor types, and educate patients about to commence therapy with these approaches regarding the potential development of adverse events and what to do if they are suspected.
    • Recall strategies commonly employed to identify, manage and mitigate toxicities resulting from anticancer treatment with ADCs, and use this information to appropriately intervene for patients in whom these side effects are suspected or diagnosed.
    • Understand the role of multidisciplinary specialists such as cardiologists, ophthalmologists and other medical professionals in the diagnosis and management of various ADC-associated toxicities, and effectively educate patients regarding the potential need for and importance of specialty referral.

    Accreditation Statement
    Research To Practice is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s (ANCC) Commission on Accreditation.

    Credit Designation Statements
    This educational activity for 1.5 contact hours is provided by Research To Practice.

    This activity is awarded 1.5 ANCC pharmacotherapeutic contact hours.

    Oncology Nursing Certification Corporation (ONCC)/Individual Learning Needs Assessment (ILNA) Certification Information
    The program content has been reviewed by the Oncology Nursing Certification Corporation (ONCC) and is acceptable for recertification points. To review certification qualifications please visit https://researchtopractice.com/Meetings/ONS2026/ADCs/ILNA.

    ONCC review is only for designating content to be used for recertification points and is not for NCPD accreditation. NCPD programs must be formally approved for contact hours by an acceptable accreditor/approver of nursing CE to be used for recertification by ONCC. If the NCPD provider fails to obtain formal approval to award contact hours by an acceptable accrediting/approval body, no information related to ONCC recertification or ILNA categories may be used in relation to the program.

    Credit Form
    To obtain a certificate of completion and receive credit for this event, nurses must attend the entire activity and return a completed Educational Assessment and Credit Form. A credit form link will be given to each participant as part of the meeting course materials.

    Privacy Policy
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    Unlabeled/Unapproved Uses Notice
    There is no implied or real endorsement of any product by Research To Practice or the American Nurses Credentialing Center.

    Content Validation and Disclosures
    Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. Any individuals in a position to control the content of an accredited continuing education activity, including faculty, planners, reviewers and others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant financial relationships will have been mitigated prior to the commencement of this activity. In addition, all activity content is reviewed by RTP scientific staff and an external, independent reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

    FACULTY — The following faculty reported relevant financial relationships with ineligible entities:

    Ms ArnSpeakers Bureaus: AbbVie Inc, AstraZeneca Pharmaceuticals LP, Eisai Inc, Genmab US Inc, GSK, Merck, Pfizer Inc. Ms CarrollConsulting Agreements: AstraZeneca Pharmaceuticals LP, Lilly, Novartis. Dr GaronConsulting Agreements: AbbVie Inc, ArriVent Biopharma, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Black Diamond Therapeutics Inc, BridgeBio, Bristol Myers Squibb, Daiichi Sankyo Inc, Gilead Sciences Inc, GSK, Hexagon Bio, I-Mab Biopharma, IO Biotech, iTeos Therapeutics, LianBio, Merck, Novartis, Oxford BioTherapeutics, Pfizer Inc, Regeneron Pharmaceuticals Inc, Samsung Bioepis, Sanofi, Servier Pharmaceuticals LLC, Strata Oncology, Synthekine, TransCode Therapeutics, Verastem Inc; Contracted Research: ABL Bio, ArriVent Biopharma, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, BridgeBio, Bristol Myers Squibb, Daiichi Sankyo Inc, Genentech, a member of the Roche Group, Gilead Sciences Inc, Iovance Biotherapeutics, Lilly, Merck, Novartis, Prelude Therapeutics, Regeneron Pharmaceuticals Inc, Synthekine, TILT Biotherapeutics; Data and Safety Monitoring Boards/Committees: Bicycle Therapeutics, Nuvalent, Servier Pharmaceuticals LLC. Dr McArthurAdvisory Committees: Arvinas, AstraZeneca Pharmaceuticals LP, Boston Scientific Corporation, Celcuity, Daiichi Sankyo Inc, Delcath Systems Inc, Genentech, a member of the Roche Group, Gilead Sciences Inc, Lilly, Merck, Novartis, Pfizer Inc; Consulting Agreements: ALX Oncology.

    MODERATORDr MooreAdvisory Committees: AstraZeneca Pharmaceuticals LP, Corcept Therapeutics Inc, GSK, Mersana Therapeutics Inc; Consulting Agreements: Aadi Bioscience, AbbVie Inc, AstraZeneca Pharmaceuticals LP, BioNTech SE, Caris Life Sciences, Corcept Therapeutics Inc, Daiichi Sankyo Inc, Duality Biologics, GSK, ImmunoGen Inc, Janssen Biotech Inc, Merck, Regeneron Pharmaceuticals Inc, Schrödinger, Takeda Pharmaceuticals USA Inc, Verastem Inc, Whitehawk Therapeutics, Zentalis Pharmaceuticals, Zymeworks Inc; Contracted Research: Accent Therapeutics, Advaxis Inc, Allarity Therapeutics, AstraZeneca Pharmaceuticals LP, Daiichi Sankyo Inc, GSK, Immunocore, Iovance Biotherapeutics, Regeneron Pharmaceuticals Inc, Schrödinger, Verastem Inc; Data and Safety Monitoring Boards/Committees: Bicycle Therapeutics; Nonrelevant Financial Relationships: ASCO, GOG Partners, NRG Oncology.

    RESEARCH TO PRACTICE NCPD PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS
    Planners, scientific staff and independent reviewers for Research To Practice have no relevant financial relationships to disclose.

    Supporters
    This activity is supported by educational grants from AstraZeneca Pharmaceuticals LP, Daiichi Sankyo Inc, and Merck.

    Location
    San Antonio Marriott Rivercenter
    101 Bowie St
    San Antonio, TX 78205
    Hotel Phone: (210) 223-1000

    Meeting Room
    Grand Ballroom A-F (Third Floor)

    Directions
    The Marriott Rivercenter hotel is conveniently located within walking distance (1.5 blocks) of the Henry B González Convention Center, where the 2026 ONS Congress is taking place.

     

    Registration is now closed.

    The Optimal Implementation of Antibody-Drug Conjugates in the Care of Patients with Cancer

    Accreditation types: 1.75 NCPD

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    Faculty

    Marianne J Davies

    Faculty

    Marianne J Davies

    DNP, ACNP, AOCNP, FAAN

    Yale New Haven Health, New Haven, Connecticut

    Program Manager, Care Signature, Oncology Service Line

    Yale Cancer Center, Smilow Cancer Hospital at Yale New Haven, New Haven, Connecticut

    Oncology Nurse Practitioner-Senior APP II

    Yale University School of Nursing, New Haven, Connecticut

    Associate Professor

    Edward B Garon

    Faculty

    Edward B Garon

    MD, MS

    David Geffen School of Medicine at UCLA, Jonsson Comprehensive Cancer Center, Los Angeles, California

    Professor, Director, Thoracic Oncology Program, Director, Signal Transduction and Therapeutics Research Program

    Marissa Marti-Smith

    Faculty

    Marissa Marti-Smith

    DNP, APRN, AGNP-C, AOCNP

    Texas Oncology-Baylor Charles A Sammons Cancer Center, Dallas, Texas

    Nurse Practitioner

    Tiffany A Traina

    Faculty

    Tiffany A Traina

    MD, FASCO

    Memorial Sloan Kettering Cancer Center, New York, New York

    Vice Chair, Department of Medicine, Section Head, Triple-Negative Breast Cancer Clinical Research Program, Associate Attending Physician, Breast Medicine Service

    Weill Cornell Medical College, New York, New York

    Associate Professor

    TARGET AUDIENCE
    This activity has been designed to meet the educational needs of oncology nurses, nurse practitioners and clinical nurse specialists involved in the treatment of cancer.

    PURPOSE STATEMENT
    By providing information on the latest research developments in the context of expert perspectives, this NCPD activity will assist oncology nurses, nurse practitioners and clinical nurse specialists with the formulation of state-of-the-art clinical management strategies to facilitate optimal care of patients with cancer.

    LEARNING OBJECTIVES

    • Consider the scientific justification for the use of antibody-drug conjugates (ADCs) as a therapeutic approach for patients with various tumor types, and recall the targets, structural components and mechanisms of activity of different clinically available and investigational agents in this class.
    • Appraise available clinical research data with novel ADCs for various cancers, and consider the current and potential role of these approaches in routine clinical care.
    • Appreciate the pathophysiology and severity of common and rare toxicities associated with ADCs employed in the treatment of different tumor types.
    • Understand the incidence of toxicities observed in pivotal trials evaluating novel ADCs, and educate patients about to commence therapy with these approaches regarding the potential development of these adverse events and what to do if they are suspected.
    • Recall strategies commonly employed to identify, manage and mitigate resultant toxicities of anticancer treatment with ADCs, and use this information to appropriately intervene for patients in whom these side effects are suspected or diagnosed.
    • Understand the role of multidisciplinary specialists such as cardiologists, ophthalmologists and other medical professionals in the diagnosis and management of ADC-associated toxicities, and effectively educate patients regarding the potential need for and importance of specialty referral.

    ACCREDITATION STATEMENT
    Research To Practice (RTP) is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s (ANCC) Commission on Accreditation.

    CREDIT DESIGNATION STATEMENT
    Video Program: This educational activity for 1.75 contact hours is provided by RTP during the period of April 2025 to April 2026.

    This activity is awarded 1.75 ANCC pharmacotherapeutic contact hours.

    ONCC/ILNA CERTIFICATION INFORMATION
    The program content has been reviewed by the ONCC and is acceptable for recertification points. Learners must apply for NCPD credit to utilize this program for ONCC certification or renewal. To review certification qualifications please visit https://www.researchtopractice.com/Meetings/ONS2025/ADCs/ILNA.

    ONCC review is only for designating content to be used for ILNA points and is not for NCPD accreditation. NCPD programs must be formally approved for contact hours by an acceptable accreditor/approver of nursing CE to be used for recertification by ONCC. If the NCPD provider fails to obtain formal approval to award contact hours by an acceptable accrediting/approval body, no information related to ONCC recertification or ILNA categories may be used in relation to the program.

    PRIVACY POLICY
    Personal information and data sharing: Research To Practice aggregates deidentified user data for program-use analysis, program development, activity planning and site improvement. We may provide aggregate and deidentified data to third parties, including commercial supporters. We do not share or sell personally identifiable information to any unaffiliated third parties or commercial supporters. Please see our privacy policy at ResearchToPractice.com/Privacy-Policy for more information.

    FOR SUCCESSFUL COMPLETION
    Video Program: This NCPD activity consists of a video component. To receive credit, the participant should review the NCPD information, watch the video, complete the post-test with a score of 80% or better and fill out the evaluation located at ResearchToPractice.com/ONS2025/ADCsPanTumor/Video/NCPD.

    CONTENT VALIDATION AND DISCLOSURES
    Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education and adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of an accredited continuing education activity, including faculty, planners, reviewers and others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of this activity. In addition, all activity content is reviewed by RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

    FACULTY — The following faculty reported relevant financial relationships with ineligible entities:

    Marianne J Davies, DNP, ACNP, AOCNP, FAAN
    Program Manager, Care Signature
    Oncology Service Line, Yale New Haven Health
    Oncology Nurse Practitioner-Senior APP II
    Yale Cancer Center
    Smilow Cancer Hospital at Yale New Haven
    Associate Professor
    Yale University School of Nursing
    New Haven, Connecticut

    No relevant conflicts of interest to disclose.

    Edward B Garon, MD, MS
    Professor
    Director, Thoracic Oncology Program
    Director, Signal Transduction and Therapeutics Research Program
    David Geffen School of Medicine at UCLA
    Jonsson Comprehensive Cancer Center
    Los Angeles, California

    Advisory Committees and Consulting Agreements: AbbVie Inc, Arcus Biosciences, ArriVent Biopharma, AstraZeneca Pharmaceuticals LP, Atreca, Black Diamond Therapeutics Inc, BridgeBio, Bristol Myers Squibb, EMD Serono Inc, Gilead Sciences Inc, Hookipa Pharma Inc, I-Mab Biopharma, LianBio, Lilly, Merck, Merus, Novartis, Nuvalent, Pfizer Inc, Regeneron Pharmaceuticals Inc, Sanofi, Seagen Inc, Sensei Biotherapeutics, Strata Oncology, Sumitomo Dainippon Pharma Oncology Inc, Summit Therapeutics, Synthekine; Contracted Research: ABL Bio, ArriVent Biopharma, AstraZeneca Pharmaceuticals LP, BridgeBio, Bristol Myers Squibb, Daiichi Sankyo Inc, EMD Serono Inc, Genentech, a member of the Roche Group, Gilead Sciences Inc, Iovance Biotherapeutics, Lilly, Merck, Mirati Therapeutics Inc, Novartis, Prelude Therapeutics, Regeneron Pharmaceuticals Inc, Synthekine, TILT Biotherapeutics; Sponsored Independent Medical Education: Daiichi Sankyo Inc; Travel: A2 Bio, Novartis.

    Marissa Marti-Smith, DNP, APRN, AGNP-C, AOCNP
    Nurse Practitioner
    Texas Oncology-Baylor Charles A Sammons Cancer Center
    Dallas, Texas

    Speakers Bureaus: Biotheranostics Inc, Stemline Therapeutics Inc; Nonrelevant Financial Relationships: ASCO Advantage, Clinical Education Alliance.

    Tiffany A Traina, MD, FASCO
    Vice Chair, Department of Medicine
    Section Head, Triple-Negative Breast Cancer Clinical Research Program
    Associate Attending Physician
    Breast Medicine Service
    Memorial Sloan Kettering Cancer Center
    Associate Professor
    Weill Cornell Medical College
    New York, New York

    Advisory Committees and Consulting Agreements: Aktis Oncology, AstraZeneca Pharmaceuticals LP, BioNTech SE, Daiichi Sankyo Inc, Ellipses Pharma, Exact Sciences Corporation, Genentech, a member of the Roche Group, Gilead Sciences Inc, GSK, Merck, Pfizer Inc, Stemline Therapeutics Inc, TerSera Therapeutics LLC, Veracyte Inc; Contracted Research: Astellas, AstraZeneca Pharmaceuticals LP, BioNTech SE, Daiichi Sankyo Inc, Genentech, a member of the Roche Group, Pfizer Inc.

    MODERATOR — Dr Love is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop NCPD activities from the following companies: AbbVie Inc, ADC Therapeutics, Alexion Pharmaceuticals, Amgen Inc, Array BioPharma Inc, a subsidiary of Pfizer Inc, Arvinas, Astellas, AstraZeneca Pharmaceuticals LP, Aveo Pharmaceuticals, Bayer HealthCare Pharmaceuticals, BeiGene Ltd, Black Diamond Therapeutics Inc, Blueprint Medicines, Boehringer Ingelheim Pharmaceuticals Inc, Bristol Myers Squibb, Clovis Oncology, Coherus BioSciences, CTI BioPharma, a Sobi Company, Daiichi Sankyo Inc, Eisai Inc, Elevation Oncology Inc, Exact Sciences Corporation, Exelixis Inc, Genentech, a member of the Roche Group, Genmab US Inc, Geron Corporation, Gilead Sciences Inc, GSK, Hologic Inc, ImmunoGen Inc, Incyte Corporation, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Jazz Pharmaceuticals Inc, Karyopharm Therapeutics, Kite, A Gilead Company, Legend Biotech, Lilly, MEI Pharma Inc, Merck, Mersana Therapeutics Inc, Mirati Therapeutics Inc, Mural Oncology Inc, Natera Inc, Novartis, Novartis Pharmaceuticals Corporation on behalf of Advanced Accelerator Applications, Novocure Inc, Nuvalent, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Rigel Pharmaceuticals Inc, R-Pharm US, Sanofi, Seagen Inc, Servier Pharmaceuticals LLC, SpringWorks Therapeutics Inc, Stemline Therapeutics Inc, Syndax Pharmaceuticals, Taiho Oncology Inc, Takeda Pharmaceuticals USA Inc, TerSera Therapeutics LLC, and Tesaro, A GSK Company.

    RESEARCH TO PRACTICE NCPD PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS — Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.

    These educational activities contain discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.

    These activities are supported by educational grants from AstraZeneca Pharmaceuticals LP and Daiichi Sankyo Inc.

    Release date: April 2025
    Expiration date: April 2026

    There is no implied or real endorsement of any product by RTP or the American Nurses Credentialing Center.

    Dr Traina

    Module 2: Trastuzumab Deruxtecan (T-DXd) in Patients with HER2-Positive Metastatic Breast Cancer (mBC) with and without Brain Metastases

    André F et al. A pooled analysis of trastuzumab deruxtecan in patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer with brain metastases. Ann Oncol 2024;35(12):1169-80. Abstract

    Cortés J et al. Trastuzumab deruxtecan versus trastuzumab emtansine in HER2-positive metastatic breast cancer: Long-term survival analysis of the DESTINY-Breast03 trial. Nat Med 2024;30(8):2208-15. Abstract

    Curigliano G et al. Tucatinib versus placebo added to trastuzumab and capecitabine for patients with pretreated HER2+ metastatic breast cancer with and without brain metastases (HER2CLIMB): Final overall survival analysis. Ann Oncol 2022;33(3):321-9. Abstract

    Hamilton EP et al. Trastuzumab deruxtecan (T-DXd) vs trastuzumab emtansine (T-DM1) in patients (pts) with HER2+ metastatic breast cancer (mBC): Updated survival results of DESTINY-Breast03. ASCO 2024;Abstract 1025.

    Harbeck N et al. Trastuzumab deruxtecan in HER2-positive advanced breast cancer with or without brain metastases: A phase 3b/4 trial. Nat Med 2024;30(12):3717-27. Abstract

    Hurvitz SA et al. A pooled analysis of trastuzumab deruxtecan (T-DXd) in patients (pts) with HER2-positive (HER2+) metastatic breast cancer (mBC) with brain metastases (BMs) from DESTINY-Breast (DB) -01, -02, and -03. ESMO 2023;Abstract 377O.

    Murthy RK et al. Tucatinib, trastuzumab, and capecitabine for HER2-positive metastatic breast cancer. N Engl J Med 2020;382(7):597-609. Abstract

    Saura C et al. Trastuzumab deruxtecan in previously treated patients with HER2-positive metastatic breast cancer: Updated survival results from a phase II trial (DESTINY-Breast01). Ann Oncol 2024;35(3):302-7. Abstract

    Swain SM et al. Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA): End-of-study results from a double-blind, randomised, placebo-controlled, phase 3 study. Lancet Oncol 2020;21(4):519-30. Abstract

     

    Module 3: Role of ADCs for Patients with ER-Positive mBC

    Bardia A et al. Trastuzumab deruxtecan after endocrine therapy in metastatic breast cancer. N Engl J Med 2024;391(22):2110-22. Abstract

    Bardia A et al. Datopotamab deruxtecan (Dato-DXd) vs chemotherapy in previously-treated inoperable or metastatic hormone receptor-positive, HER2-negative (HR+/HER2–) breast cancer (BC): Primary results from the randomised phase III TROPION-Breast01 trial. ESMO 2023;Abstract LBA11.

    Bardia A et al. Randomized phase 3 study of datopotamab deruxtecan vs chemotherapy for patients with previously-treated inoperable or metastatic hormone receptor-positive, HER2-negative breast cancer: Results from TROPION-Breast01. San Antonio Breast Cancer Symposium 2023;Abstract GS02-01.

    Curigliano G et al. Trastuzumab deruxtecan (T-DXd) vs physician’s choice of chemotherapy (TPC) in patients (pts) with hormone receptor-positive (HR+), human epidermal growth factor receptor 2 (HER2)-low or HER2-ultralow metastatic breast cancer (mBC) with prior endocrine therapy (ET): Primary results from DESTINY-Breast06 (DB-06). ASCO 2024;Abstract LBA1000.

    Huppert LA et al. Multicenter retrospective cohort study of the sequential use of the antibody-drug conjugates (ADCs) trastuzumab deruxtecan (T-DXd) and sacituzumab govitecan (SG) in patients with HER2-low metastatic breast cancer (MBC): Updated data and subgroup analyses by age, sites of disease, and use of intervening therapies. ASCO 2024;Abstract 1083.

    Modi S et al. Trastuzumab deruxtecan (T-DXd) versus treatment of physician’s choice (TPC) in patients (pts) with HER2-low unresectable and/or metastatic breast cancer (mBC): Updated survival results of the randomized, phase III DESTINY-Breast04 study. ESMO 2023;Abstract 376O.

    Rugo HS et al. Overall survival with sacituzumab govitecan in hormone receptor-positive and human epidermal growth factor receptor 2-negative metastatic breast cancer (TROPiCS-02): A randomised, open-label, multicentre, phase 3 trial. Lancet 2023;402(10411):1423-33. Abstract

    Rugo HS et al. Primary results from TROPiCS-02: A randomized phase 3 study of sacituzumab govitecan (SG) versus treatment of physician’s choice (TPC) in patients (Pts) with hormone receptor–positive/HER2-negative (HR+/HER2-) advanced breast cancer. ASCO 2022;Abstract LBA1001.

    Tolaney SM et al. Final overall survival (OS) analysis from the phase 3 TROPiCS-02 study of sacituzumab govitecan (SG) in patients (pts) with hormone receptor–positive/HER2-negative (HR+/HER2–) metastatic breast cancer (mBC). ASCO 2023;Abstract 1003.

     

    Ms Marti-Smith

    Module 2: Overview of Antibody-Drug Conjugates (ADCs)

    Rugo HS et al. Real-world perspectives and practices for pneumonitis/interstitial lung disease associated with trastuzumab deruxtecan use in human epidermal growth factor receptor 2-expressing metastatic breast cancer. JCO Oncol Pract 2023;19(8):539-46. Abstract

     

    Module 3: Role of ADCs for Patients with ER-Positive mBC

    Spring LM et al. Sacituzumab govitecan for metastatic triple-negative breast cancer: Clinical overview and management of potential toxicities. Oncologist 2021;26(10):827-34. Abstract

     

    Dr Garon

    Module 4: T-DXd in Patients with Metastatic Non-Small Cell Lung Cancer (NSCLC) with HER2 Alterations

    Goto K et al. Trastuzumab deruxtecan in patients with HER2-mutant metastatic non-small-cell lung cancer: Primary results from the randomized, phase II DESTINY-Lung02 trial. J Clin Oncol 2023;41(31):4852-63. Abstract

    Janne PA et al. Trastuzumab deruxtecan (T-DXd) in patients with HER2-mutant metastatic non–small cell lung cancer (mNSCLC): Final analysis results of DESTINY-Lung02. ASCO 2024;Abstract 8543.

    Li BT et al. Trastuzumab deruxtecan in HER2-mutant non-small-cell lung cancer. N Engl J Med 2022;386(3):241-51. Abstract

    Odintsov I et al. Prevalence and therapeutic targeting of high-level ERBB2 amplification in NSCLC. J Thorac Oncol 2024;19(5):732-48. Abstract

    Planchard D et al. Trastuzumab deruxtecan monotherapy in pretreated HER2-overexpressing nonsquamous non-small cell lung cancer: DESTINY-Lung03 part 1. WCLC 2024;Abstract OA16.05.

    Uzunparmak B et al. HER2-low expression in patients with advanced or metastatic solid tumors. Ann Oncol 2023;34(11):1035-46. Abstract

    Waliany S et al. Real-world prevalence, treatment patterns, and outcomes for patients with HER2 (ERBB2)-mutant metastatic non-small cell lung cancer, from a US-based clinico-genomic database. Cancer Med 2024;13(24):e70272. Abstract

     

    Module 5: Emerging Role of ADCs for Patients with Progressive EGFR-Mutant NSCLC

    Ahn M et al. Datopotamab deruxtecan (Dato-DXd) vs docetaxel in previously treated advanced/metastatic (adv/met) non-small cell lung cancer (NSCLC): Results of the randomized phase III study TROPION-Lung01. ESMO 2023;Abstract LBA12.

    Krop IE et al. Results from the phase 1/2 study of patritumab deruxtecan, a HER3-directed antibody-drug conjugate (ADC), in patients with HER3-expressing metastatic breast cancer (MBC). ASCO 2022;Abstract 1002.

    Paz-Ares L et al. TROPION-Lung05: Datopotamab deruxtecan (Dato-DXd) in previously treated non-small cell lung cancer (NSCLC) with actionable genomic alterations (AGAs). ESMO 2023;Abstract 1314MO.

    Sands J et al. Datopotamab deruxtecan vs docetaxel in patients with non-small cell lung cancer: Final overall survival from TROPION-Lung01. WCLC 2024;Abstract OA08.03.

    Yu HA et al. HERTHENA-Lung01, a phase II trial of patritumab deruxtecan (HER3-DXd) in epidermal growth factor receptor-mutated non-small-cell lung cancer after epidermal growth factor receptor tyrosine kinase inhibitor therapy and platinum-based chemotherapy. J Clin Oncol 2023;41(35):5363-75. Abstract

     

    Ms Davies

    Module 4: T-DXd in Patients with Metastatic Non-Small Cell Lung Cancer (NSCLC) with HER2 Alterations

    Tarantino P, Tolaney SM. Detecting and managing T-DXd-related interstitial lung disease: The five “S” rules. JCO Oncol Pract 2023;19(8):526-7. Abstract

    Tarantino P et al. Interstitial lung disease induced by anti-ERBB2 antibody-drug conjugates: A review. JAMA Oncol 2021;7(12):1873-81. Abstract

     

    Module 5: Emerging Role of ADCs for Patients with Progressive EGFR-Mutant NSCLC

    Heist RS et al. Clinical management, monitoring, and prophylaxis of adverse events of special interest associated with datopotamab deruxtecan. Cancer Treat Rev 2024;125:102720. Abstract

    • for-nurses