Data + Perspectives: Investigators Discuss the Optimal Management of Relapsed/Refractory Multiple Myeloma

Join us on Wednesday, September 9^th from 11:56 AM to 12:56 PM central time (12:56 PM to 1:56 PM eastern time).

Educational Lunch Meeting

In-person attendees, please check in 15 minutes before the start of the meeting.

Module 1: Integrating Bispecific Antibodies into the Management of Relapsed/Refractory (R/R) Multiple Myeloma (MM) 

• Similarities and differences in the cellular targets and mechanisms of action of the various bispecific antibodies for MM 

• Available efficacy and safety findings leading to the FDA approvals of the BCMA-directed bispecific antibodies teclistamab, elranatamab and linvoseltamab and the GPRC5D-targeted bispecific antibody talquetamab for heavily pretreated MM; optimal incorporation into current management algorithms 

• Published findings from the Phase III MajesTEC-3 trial supporting the recent FDA approval of teclistamab in combination with subcutaneous daratumumab for patients with R/R MM after ≥1 prior line of treatment 

• Positive findings from published (MajesTEC-9) and emerging (MagnetisMM-5) Phase III studies evaluating BCMA-targeted bispecific antibodies as monotherapy in earlier lines of treatment 

• Recently presented results of the Phase III 
  MonumenTAL-3 trial of talquetamab combined with daratumumab with and without pomalidomide for R/R MM after ≥1 prior line of therapy; potential role of this approach 

• Emerging positive findings from and implications of the Phase III MonumenTAL-6 trial of talquetamab in combination with teclistamab or pomalidomide after 1 to 4 prior lines of therapy 

• Biological rationale for and published findings with the FcRH5-directed bispecific antibody cevostamab for R/R MM; ongoing Phase III CEVOLUTION trial combining cevostamab with pomalidomide and dexamethasone 

MODULE 2: Utility of Antibody-Drug Conjugates for R/R MM 

• Mechanism of action and structural components of belantamab mafodotin 

• Historical efficacy and safety findings with belantamab mafodotin monotherapy for patients with R/R MM 

• Extended efficacy and safety data from the Phase III DREAMM-7 and DREAMM-8 trials evaluating belantamab mafodotin in combination with bortezomib/dexamethasone and pomalidomide/dexamethasone, respectively, for patients who have received ≥1 prior line of therapy; overall survival findings from DREAMM-7 

• FDA approval and current role of belantamab mafodotin/bortezomib/dexamethasone in the management of R/R MM 

• Incidence, severity, mitigation and management of belantamab mafodotin-related adverse events, including ocular toxicities 

• Ongoing studies attempting to further elucidate the role of belantamab mafodotin for MM 

MODULE 3: Potential Role of Cereblon E3 Ligase Modulators (CELMoDs) and Other Promising Novel Agents and Strategies for R/R MM 

• Mechanism of action of CELMoDs; similarities and differences among iberdomide, mezigdomide and standard immunomodulatory drugs 

• Emerging findings from the Phase III EXCALIBER-RRMM study indicating an improvement in minimal residual disease negativity rates with iberdomide/daratumumab/dexamethasone versus daratumumab/bortezomib/dexamethasone for R/R MM 

• Recently presented data from the Phase III SUCCESSOR-2 trial assessing mezigdomide/carfilzomib/dexamethasone versus carfilzomib/dexamethasone for R/R MM 

• Ongoing FDA review of new drug applications for iberdomide in combination with daratumumab/dexamethasone and mezigdomide in combination with carfilzomib/dexamethasone for patients with R/R MM, the former with priority review status; potential role of these regimens 

• Other ongoing studies evaluating CELMoD-containing therapy for newly diagnosed and R/R MM; potential clinical role 

• Rationale for the evaluation of chimeric antigen receptor (CAR) T-cell platforms with novel targets or manufacturing processes for R/R MM 

• Early data with the GPRC5D-targeted CAR T-cell therapy arlocabtagene autoleucel for R/R MM; FDA Regenerative Medicine Advanced Therapy Designation and ongoing evaluation in the QUINTESSENTIAL and QUINTESSENTIAL-2 studies 

• Other promising novel strategies in clinical development for patients with R/R MM 

Target Audience
This activity has been designed to meet the educational needs of hematologists, hematology-oncology fellows, medical oncologists and other healthcare professionals involved in the treatment of multiple myeloma.

Learning Objectives
Upon completion of this activity, participants should be able to

• Consider published research findings and other clinical factors affecting the best-practice sequencing of established and novel agents and regimens in the care of patients with relapsed/refractory (R/R) multiple myeloma (MM). 
• Assess available and emerging research data with B-cell maturation antigen (BCMA)-directed and non-BCMA-directed bispecific antibodies for MM in order to appropriately integrate these agents into current clinical algorithms.
• Recall recently presented clinical research findings establishing the definitive efficacy of BCMA-directed antibody-drug conjugate therapy for patients with R/R MM. 
• Analyze the mechanism of action of, published and emerging efficacy and safety findings with and ongoing research efforts evaluating cereblon E3 ligase modulators (CELMoDs) in order to identify patients with R/R MM who are optimal candidates for CELMoD-containing regimens.  
• Implement a plan of care to recognize and manage class-effect and agent-specific toxicities associated with therapies commonly employed in the care of patients with R/R MM. 
• Recall available data with novel agents and strategies currently under investigation for R/R MM, and discuss clinical trial participation with eligible patients. 

CE Credit
CME credit information will be given to each participant as part of the meeting course materials.

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Research To Practice is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation Statement
Research To Practice designates this live activity for a maximum of 1 AMA PRA Category 1 Credits^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

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Unlabeled/Unapproved Uses Notice
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the provider or grantors.

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FACULTY
Prof Dimopoulos — Advisory Committees and Consulting Agreements: Amgen Inc, AstraZeneca Pharmaceuticals LP, BeOne, Bristol Myers Squibb, GSK, Janssen Biotech Inc, Menarini Group, Regeneron Pharmaceuticals Inc, Sanofi, Swixx Biopharma, Takeda Pharmaceutical Company Limited. Dr Raje — Advisory Boards and Consulting Agreements: AbbVie Inc, Bristol Myers Squibb, Caribou Biosciences Inc, GSK, Immuneel Therapeutics, Johnson & Johnson, Kelonia Therapeutics, Pfizer Inc, Sanofi; Contracted Research: Pfizer Inc; Data and Safety Monitoring Boards/Committees: Bristol Myers Squibb. Dr Richardson — Consulting Agreements: Bristol Myers Squibb, Celgene Corporation, GSK, Karyopharm Therapeutics, Oncopeptides, Regeneron Pharmaceuticals Inc, Sanofi; Contracted Research: Karyopharm Therapeutics, Oncopeptides.

MODERATOR
Dr Orlowski — Advisory Committees and Consulting Agreements: AbbVie Inc, Adaptive Biotechnologies Corporation, Asylia Therapeutics Inc, Biotheryx, Bristol Myers Squibb, DEM BioPharma, GSK, IASO Bio, Karyopharm Therapeutics, Lytica Therapeutics, Meridian Therapeutics, Monte Rosa Therapeutics, MYELOMA360, Neurogene Inc, Oncopeptides, Pfizer Inc, Regeneron Pharmaceuticals Inc, Sanofi, Sporos Bioventures, Takeda Pharmaceuticals USA Inc; Contracted Research: Asylia Therapeutics Inc, Biotheryx, Heidelberg Pharma, Regeneron Pharmaceuticals Inc; Data and Safety Monitoring Boards/Committees: Sanofi.

EDITOR
Dr Love is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop CME activities from the following companies: Aadi Bioscience, AbbVie Inc, ADC Therapeutics, Agendia Inc, Alexion Pharmaceuticals, Amgen Inc, Array BioPharma Inc, a subsidiary of Pfizer Inc, Arvinas, Astellas, AstraZeneca Pharmaceuticals LP, Aveo Pharmaceuticals, Bayer HealthCare Pharmaceuticals, BeOne, Biotheranostics Inc, A Hologic Company, Black Diamond Therapeutics Inc, Blueprint Medicines, Boehringer Ingelheim Pharmaceuticals Inc, Bristol Myers Squibb, Catalyst Pharmaceuticals Inc, Celcuity, Clovis Oncology, Coherus BioSciences, Corcept Therapeutics Inc, CTI BioPharma, a Sobi Company, Daiichi Sankyo Inc, Eisai Inc, Elevation Oncology Inc, Exact Sciences Corporation, Exelixis Inc, Genentech, a member of the Roche Group, Genmab US Inc, Geron Corporation, Gilead Sciences Inc, GSK, Helsinn Therapeutics (US) Inc, ImmunoGen Inc, Incyte Corporation, Ipsen Biopharmaceuticals Inc, Jazz Pharmaceuticals Inc, Johnson & Johnson, Karyopharm Therapeutics, Kite, A Gilead Company, Kura Oncology, Legend Biotech, Lilly, MEI Pharma Inc, Merck, Mersana Therapeutics Inc, Mirati Therapeutics Inc, Mural Oncology Inc, Natera Inc, Novartis, Novartis Pharmaceuticals Corporation on behalf of Advanced Accelerator Applications, Novocure Inc, Nuvalent, Nuvation Bio Inc, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Revolution Medicines Inc, Rigel Pharmaceuticals Inc, R-Pharm US, Sanofi, Seagen Inc, Servier Pharmaceuticals LLC, SpringWorks Therapeutics Inc, Stemline Therapeutics Inc, Sumitomo Pharma America, Summit Therapeutics, Syndax Pharmaceuticals, Taiho Oncology Inc, Takeda Pharmaceuticals USA Inc, TerSera Therapeutics LLC, Tesaro, A GSK Company, and Verastem Inc.

Research To Practice CME Planning Committee Members, Staff and Reviewers
Planners, scientific staff and independent reviewers for Research To Practice have no relevant financial relationships to disclose.

Supporters
This activity is supported by educational grants from Bristol Myers Squibb, Genentech, a member of the Roche Group, and GSK.

George R Brown Convention Center
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Meeting Room
Level 3 in Grand Ballroom B (Theater Room 2)

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