Sixth Annual National General Medical Oncology Summit

A Multitumor CME/MOC-, NCPD- and ACPE-Accredited Educational Conference Developed in Partnership with Florida Cancer Specialists & Research Institute

Note from the Moderator
This coming April 23rd marks the return of our annual National General Medical Oncology Summit. To include community perspectives, we are pleased to be partnering again with Florida Cancer Specialists & Research Institute for this one-of-a-kind offering that will span 3 days and feature a stellar multidisciplinary faculty panel of clinical investigators and a unique blend of short didactic presentations, lively moderated panel discussions and dedicated Q&A sessions. The conference’s educational design and the topics that will be discussed offer interested clinicians access to the in-depth perspectives of some of the top minds in the field regarding significant new datasets, promising treatment strategies and key interdisciplinary management considerations in the care of patients with cancer. We hope you will join us in sunny Florida for a learning experience unlike any other out there.

Program Schedule — Eastern Time
Friday to Sunday, April 23 to 25, 2027

Location
The Ritz-Carlton Orlando, Grande Lakes
4012 Central Florida Parkway
Orlando, Florida
Hotel Phone: (407) 206-2400

Meeting Room
Ritz Carlton Ballroom (Salons I-III) — Lobby Level

Room Reservations
A special discounted room rate of $429 per night (plus applicable tax and discounted resort fee) is available to conference attendees at The Ritz-Carlton Orlando, Grande Lakes. Please see the Location tab for details.

No registration fee. Preregistration is required for in-person attendance in Orlando as seating is limited.

Neil Love

Moderator

Neil Love

MD

Research To Practice

Miami, Florida

Faculty to be announced.

Join us from Friday, April 23 to Sunday, April 25, 2027.

Preliminary Agenda
A detailed agenda and speaker information will be made available in the coming months. Times and schedule are subject to change.

Friday, April 23rd
6:30 PM – 7:00 PM Welcome Reception
7:00 PM – 9:00 PM Keynote Session

Saturday, April 24th
7:00 AM – 7:45 AM Breakfast
7:45 AM – 12:30 PM Morning General Session
12:30 PM – 1:15 PM Lunch
1:15 PM – 5:30 PM Afternoon Breakout Sessions

Sunday, April 25th
7:00 AM – 7:45 AM Breakfast
7:45 AM – 12:15 PM Morning General Session
12:15 PM – 1:00 PM Lunch
1:00 PM – 3:30 PM Afternoon General Session

Target Audience
This activity has been designed to meet the educational needs of medical oncologists, hematologists, hematology-oncology fellows, surgeons, radiation oncologists, pharmacists, nurse practitioners, clinical nurse specialists and other healthcare professionals involved in the treatment of cancer.

Learning Objectives
To be announced.

CE Credit
CME, ABIM MOC, ABS and ACPE credit information will be given to each participant as part of the meeting course materials.

NCPD Credit
To obtain a certificate of completion and receive credit for this event, nurses must attend the entire activity and return a completed Educational Assessment and Credit Form. A credit form link will be given to each participant as part of the meeting course materials.

CME Accreditation Statement
Research To Practice is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CME Credit Designation Statement
To be announced.

American Board of Internal Medicine (ABIM) — Maintenance of Certification (MOC)
Successful completion of this CME activity, which includes participation in the evaluation component and a post-test, enables the participant to earn Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Please note, this program has been specifically designed for the following ABIM specialties: medical oncology and hematology.

American Board of Surgery (ABS) — Continuous Certification (CC)
Successful completion of this CME activity, which includes participation in the evaluation component and a post-test, enables the learner to earn Medical Knowledge MOC points toward the CME and Self-Assessment requirement(s) of the American Board of Surgery’s Continuous Certification program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABS credit.

Please note, this program has been specifically designed for the following ABS practice area: complex general surgical oncology.

NCPD Accreditation Statement
Research To Practice is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation.

Number of Contact Hours Awarded
To be announced.

ONCC/Individual Learning Needs Assessment (ILNA) Certification Information
This activity will be remitted for ONCC/ILNA approval.

ACPE Accreditation Statement
The University of Texas at Austin College of Pharmacy Continuing Professional Development will provide the ACPE accreditation for this course. The University of Texas at Austin College of Pharmacy is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education.

ACPE Credit Designation Statement
To be announced.

Privacy Policy
Personal information and data sharing: Research To Practice aggregates deidentified user data for program-use analysis, program development, activity planning and site improvement. We may provide aggregate and deidentified data to third parties, including commercial supporters. We do not share or sell personally identifiable information to any unaffiliated third parties or commercial supporters. Please see our privacy policy at ResearchToPractice.com/Privacy-Policy for more information.

Unlabeled/Unapproved Uses Notice
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the provider or grantors.

Content Validation and Disclosures
Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education and adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of an accredited continuing education activity, including faculty, planners, reviewers and others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant financial relationships will have been mitigated prior to the commencement of this activity. In addition, all activity content is reviewed by RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations. Faculty disclosures to be provided.

FACULTY
To be announced.

MODERATOR
Dr Love
is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop CME activities from the following companies: Aadi Bioscience, AbbVie Inc, ADC Therapeutics, Agendia Inc, Alexion Pharmaceuticals, Amgen Inc, Array BioPharma Inc, a subsidiary of Pfizer Inc, Arvinas, Astellas, AstraZeneca Pharmaceuticals LP, Aveo Pharmaceuticals, Bayer HealthCare Pharmaceuticals, BeOne, Biotheranostics Inc, A Hologic Company, Black Diamond Therapeutics Inc, Blueprint Medicines, Boehringer Ingelheim Pharmaceuticals Inc, Bristol Myers Squibb, Catalyst Pharmaceuticals Inc, Celcuity, Clovis Oncology, Coherus BioSciences, Corcept Therapeutics Inc, CTI BioPharma, a Sobi Company, Daiichi Sankyo Inc, Eisai Inc, Elevation Oncology Inc, Exact Sciences Corporation, Exelixis Inc, Genentech, a member of the Roche Group, Genmab US Inc, Geron Corporation, Gilead Sciences Inc, GSK, Helsinn Therapeutics (US) Inc, ImmunoGen Inc, Incyte Corporation, Ipsen Biopharmaceuticals Inc, Jazz Pharmaceuticals Inc, Johnson & Johnson, Karyopharm Therapeutics, Kite, A Gilead Company, Kura Oncology, Legend Biotech, Lilly, MEI Pharma Inc, Merck, Mersana Therapeutics Inc, Mirati Therapeutics Inc, Mural Oncology Inc, Natera Inc, Novartis, Novartis Pharmaceuticals Corporation on behalf of Advanced Accelerator Applications, Novocure Inc, Nuvalent, Nuvation Bio Inc, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Revolution Medicines Inc, Rigel Pharmaceuticals Inc, R-Pharm US, Sanofi, Seagen Inc, Servier Pharmaceuticals LLC, SpringWorks Therapeutics Inc, Stemline Therapeutics Inc, Sumitomo Pharma America, Summit Therapeutics, Syndax Pharmaceuticals, Taiho Oncology Inc, Takeda Pharmaceuticals USA Inc, TerSera Therapeutics LLC, Tesaro, A GSK Company, and Verastem Inc.

Research To Practice CME/NCPD/ACPE Planning Committee Members, Staff and Reviewers
Planners, scientific staff and independent reviewers for Research To Practice have no relevant financial relationships to disclose.

The Ritz-Carlton Orlando, Grande Lakes
4012 Central Florida Pkwy
Orlando, FL 32837
Hotel Phone: (407) 206-2400

Meeting Room
Ritz Carlton Ballroom (Salons I-III) — Lobby Level

Room Reservations
A special discounted room rate of $429 per night and a discounted resort fee of $40 per night, plus applicable taxes, are available to conference attendees at The Ritz-Carlton Orlando, Grande Lakes.

Instructions on how to secure hotel accommodations will be included in the confirmation email after you have completed registration. Florida Cancer Specialists members, please contact FCS directly to confirm accommodations.

Room reservations must be made by Wednesday, March 24, 2027. A limited number of rooms are available, and we encourage you to make your reservations early. After Wednesday, March 24th, the hotel will offer the best rates based on room availability.

Parking
Discounted valet parking is available at $46.40 plus applicable taxes:

  • Overnight guests: The discounted rate will be automatically applied at checkout for attendees staying within the conference hotel block.
  • Daily guests: Vouchers will be provided at the registration desk each day of the conference.

Self-parking is not available at the hotel.

All parking rates are subject to change.

Program slides will be made available prior to the start of the session.

Registration to attend virtually is open to all professionals.

Please click the link to register for this live event directly on Zoom. Once you register, Zoom will send a confirmation email with your individual link to access the event. Please keep that confirmation email handy. If you do not receive it, contact our support team at meetings@researchtopractice.com.

This activity has been designed to meet the educational needs of medical oncologists, hematologists, hematology-oncology fellows, surgeons, radiation oncologists, pharmacists, nurse practitioners, clinical nurse specialists and other healthcare professionals involved in the treatment of cancer.

No registration fee is charged for this event. Preregistration is required as seating is limited.

At this time, in-person registration for this educational activity is limited to practicing clinicians. For all other professionals,* we are unable to confirm seating at this time. If you would like to be added to our standby list, please click here to complete the Standby Registration form. We will notify you should seats become available.

Virtual registration is open to all professionals. Please complete the Webcast Registration form to register for virtual attendance.

 

* Individuals employed by for-profit organizations, including financial institutions and biotech or pharmaceutical companies.

Registration

Name(Required)
Address(Required)
Are you a Florida Cancer Specialists member?(Required)

Clinical background

To ensure seating and meal service, please check in at our onsite registration desk before the start of the meeting. We cannot guarantee seating after the start of the program.

Photography and/or video recording may be taken during the educational program by Research To Practice and used in future educational offerings.

Research To Practice fully complies with the legal requirements of the ADA. If you require any physical, dietary or other accommodations, please call us at (800) 233-6153 before the event.

If you have any questions, please feel free to contact us via email at Meetings@ResearchToPractice.com, or call (800) 233-6153.

Thank you for your interest. At this time registration to attend this activity in person is closed to industry professionals and nonclinicians. Please provide your contact information below if you would like to be notified should seats become available, and we will be happy to alert you. If you have any further questions, please contact us at Meetings@ResearchToPractice.com.

Standby Registration

Name(Required)
Address(Required)

Second Opinion: A Case-Based Exploration of Clinical Investigator Best Practices Related to the Management of Localized HR-Positive Breast Cancer

A CME Satellite Symposium

Program Schedule — Central Time
Thursday, December 10, 2026
6:30 PM – 7:00 PM — Registration and Dinner Buffet
7:00 PM – 9:00 PM — Educational Meeting

Location
San Antonio Marriott Rivercenter
101 Bowie St
San Antonio, Texas
Hotel Phone: (210) 223-1000

Meeting Room
To be announced.

No registration fee. Preregistration is required for in-person attendance in San Antonio as seating is limited.

Adam M Brufsky

Faculty

Adam M Brufsky

MD, PhD

UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania

Professor of Medicine, Department of Medicine

Charles E Geyer Jr

Faculty

Charles E Geyer Jr

MD

UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

Professor of Medicine, Division Chief, Malignant Hematology and Medical Oncology

NSABP Foundation, Pittsburgh, Pennsylvania

Chief Scientific Officer

NRG Oncology, Philadelphia, Pennsylvania

Associate Group Chair

Matthew P Goetz

Faculty

Matthew P Goetz

MD

Mayo Clinic, Rochester, Minnesota

Erivan K Haub Family Professor of Cancer Research Honoring Richard F Emslander, MD, Professor of Oncology and Pharmacology, Enterprise Deputy Director, Translational Research, Director, Mayo Clinic Breast Cancer SPORE

Rita Nanda

Moderator

Rita Nanda

MD

The University of Chicago, Chicago, Illinois

Director, Breast Oncology, Associate Professor of Medicine, Section of Hematology/Oncology

This symposium is sponsored by Research To Practice and supported by grants from Agendia Inc, AstraZeneca Pharmaceuticals LP, Biotheranostics Inc, A Hologic Company, Exact Sciences Corporation, Genentech, a member of the Roche Group, and Merck. This is not an official program of the San Antonio Breast Cancer Symposium®.

Join us on Thursday, December 10th from 7:00 PM to 9:00 PM central time (8:00 PM to 10:00 PM eastern time).

Module 1: Integration of Adjuvant CDK4/6 Inhibitor Therapy into the Current Management of High-Risk, Hormone Receptor (HR)-Positive, HER2-Negative Localized Breast Cancer 

  • Clinical and biological factors (eg, age/menopausal status, tumor size/grade, nodal involvement, genomic assay results, comorbidities) affecting the choice of adjuvant therapy for HR-positive, HER2-negative localized breast cancer; rationale for the addition of CDK4/6 inhibitors to standard adjuvant endocrine therapy for high-risk disease  
  • Long-term outcomes, including overall survival (OS) data, from the Phase III monarchE trial evaluat­ing the addition of abemaciclib to standard adju­vant hormonal therapy for patients with high-risk, HR-positive, HER2-negative localized breast cancer 
  • Extended follow-up with adjuvant ribociclib and endocrine therapy compared to endocrine therapy alone in the Phase III NATALEE trial  
  • FDA-approved indications and identification of appropriate candidates for adjuvant abemaciclib and ribociclib 
  • Other relevant studies (eg, the Phase II TRADE trial) attempting to optimize the use of CDK4/6 inhibitors in the adjuvant setting  
  • Available data with and ongoing studies evaluating CDK4/6 inhibitors as neoadjuvant therapy for local­ized HR-positive breast cancer 

Module 2: Available Data with and Practical Application of PARP Inhibition as Adjuvant Therapy for Patients with HR-Positive Localized Breast Cancer 

  • Incidence of germline BRCA1/2 mutations and other homologous recombination repair (HRR) gene mutations in patients with HR-positive, HER2-negative breast cancer; optimal approach to genetic testing  
  • Key findings, including OS data, from the Phase III OlympiA trial assessing adjuvant olaparib versus pla­cebo for patients with high-risk, HER2-negative breast cancer and germline BRCA1/2 mutations  
  • Optimal selection of candidates with high-risk, HR-positive, HER2-negative breast cancer with germline BRCA mutations for adjuvant olaparib; role, if any, for patients with other germline or somatic HRR alterations  
  • Early data with and ongoing evaluation of PARP inhibitors in the neoadjuvant setting  
  • Incidence, severity and management of toxicities asso­ciated with PARP inhibitors in the localized setting  

Module 3: Potential Use of Oral Selective Estrogen Receptor Degraders (SERDs) for HR-Positive, HER2-Negative Localized Breast Cancer 

  • Rationale for the investigation of oral SERDs as adju­vant therapy for patients with HR-positive, HER2-negative localized breast cancer 
  • Design, eligibility criteria and primary and secondary endpoints of the Phase III lidERA study evaluating adjuvant giredestrant versus physician’s choice of adjuvant endocrine monotherapy for patients with HR-positive, HER2-negative localized breast cancer 
  • Improvement in invasive disease-free survival and other key efficacy outcomes documented with adjuvant giredestrant in lidERA  
  • Tolerability profile of giredestrant versus standard adjuvant endocrine therapy in lidERA  
  • Potential clinical role of adjuvant giredestrant for patients with HR-positive, HER2-negative localized breast cancer 
  • Ongoing Phase III trials (eg, ELEGANT, TREAT ctDNA, EMBER-4, CAMBRIA-1, CAMBRIA-2) of other oral SERDs in the adjuvant or neoadjuvant setting 

Module 4: Risk Assessment and Genomic Assays for Treatment Decision-Making in HR-Positive, HER2-Negative Localized Breast Cancer  

  • Similarities and differences among available genomic assays (eg, Oncotype DX®, MammaPrint®, Prosigna®, EndoPredict®, Endocrine Activity Index®, Breast Cancer Index®)  
  • Key studies informing the use of the 21-gene Recurrence Score® (RS) to guide neoadjuvant and adjuvant treatment decision-making for patients with HR-positive, HER2-negative localized breast cancer 
  • Clinical research supporting the utility of the 70-gene signature in preoperative and adjuvant treatment planning for patients with HR-positive, HER2- negative localized breast cancer 
  • Current clinical utility of genetic tests and prog­nostic tools that complement available genomic assays (eg, the RSClin educational tool in concert with the 21-gene RS, the BluePrint® molecular subtyping test in concert with the 70-gene signature)  
  • Published research supporting the use of the Breast Cancer Index to inform extended adjuvant endo­crine therapy decision-making for patients with HR-positive localized breast cancer 

Target Audience
This activity is intended for medical oncologists, breast surgeons, radiation oncologists and other healthcare professionals involved in the diagnosis and treatment of breast cancer.

Learning Objectives
Upon completion of this activity, participants should be able to

  • Understand how various clinical and biological factors, including age/menopausal status, tumor size/grade and nodal involvement affect a patient’s risk of recurrence, and use this information to personalize the selection of adjuvant systemic therapy for individuals with newly diagnosed hormone receptor (HR)-positive, HER2-negative breast cancer. 
  • Appraise the scientific justification for, available data with and potential clinical role of oral selective estrogen receptor degraders (SERDs) as adjuvant treatment for localized estrogen recep­tor-positive, HER2-negative breast cancer.  
  • Consider available clinical trial findings with CDK4/6 inhibitors for localized HR-positive, HER2-negative breast cancer, and identify patients for whom adjuvant therapy with one of these agents would be appropriate.  
  • Recognize adverse events and other common side effects associated with different CDK4/6 inhibitors for localized breast cancer, and tailor therapy for individuals with preexisting medical conditions and relevant comorbidities.  
  • Appreciate the incidence of BRCA1/2 and other DNA damage repair mutations in patients with localized HR-positive breast cancer, and assess the role of adjuvant PARP inhibition for individuals harboring these abnormalities.  
  • Assess the similarities and differences among the various genomic assays with established prognostic and predictive utility for HR-positive localized breast cancer, and consider available research findings informing the use of these tests. 

CE Credit
CME credit information will be given to each participant as part of the meeting course materials.

Accreditation Statement
Research To Practice is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation Statement
Research To Practice designates this live activity for a maximum of 2 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Privacy Policy
Personal information and data sharing: Research To Practice aggregates deidentified user data for program-use analysis, program development, activity planning and site improvement. We may provide aggregate and deidentified data to third parties, including commercial supporters. We do not share or sell personally identifiable information to any unaffiliated third parties or commercial supporters. Please see our privacy policy at ResearchToPractice.com/Privacy-Policy for more information.

Unlabeled/Unapproved Uses Notice
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the provider or grantors.

Content Validation and Disclosures
Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education and adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of an accredited continuing education activity, including faculty, planners, reviewers and others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant financial relationships will have been mitigated prior to the commencement of this activity. In addition, all activity content is reviewed by RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations. 

FACULTY — The following faculty reported relevant financial relationships with ineligible entities:

Dr Brufsky — Consulting Agreements: Agendia Inc, AstraZeneca Pharmaceuticals LP, BriaCell, Celcuity, Daiichi Sankyo Inc, Genentech, a member of the Roche Group, Gilead Sciences Inc, Jazz Pharmaceuticals Inc, Lilly, Merck, Novartis, Pfizer Inc, Puma Biotechnology Inc; Contracted Research: Agendia Inc; Stock Options/Stock — Public Companies: Celcuity; Stock Options — Private Companies: Ataraxis. Dr Geyer — Contracted Research: Abbott, Artera, AstraZeneca Pharmaceuticals LP, Caris Life Sciences, Daiichi Sankyo Inc, Exact Sciences Corporation, Genentech, a member of the Roche Group. Dr Goetz — Advisory Committees: AstraZeneca Pharmaceuticals LP, AstraZeneca UK, Ataraxis, BeOne, Biotheranostics Inc, A Hologic Company, Biotheryx, EcoR1 Capital LLC, Genentech, a member of the Roche Group, Incyclix Bio, Puma Biotechnology Inc, Rna Diagnostics; Consulting Agreements: Genentech, a member of the Roche Group, Lilly, Novartis, Stemline Therapeutics Inc; Contracted Research: AstraZeneca Pharmaceuticals LP, Atossa Therapeutics, Biotheryx, Lilly, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Pfizer Inc, Sermonix Pharmaceuticals, SimBioSys; Data and Safety Monitoring Boards/Committees: Pfizer Inc; Personal Fees for CME Activities: DAVA Oncology; Nonrelevant Financial Relationships: AXIS Medical Education Inc, BroadcastMed, eChinaHealth, IDEOlogy Health, MJH Life Sciences, PeerView, Physician Education Resource (PER), Total Health Conferencing.

MODERATOR
Dr Nanda — Advisory Committees: AstraZeneca Pharmaceuticals LP, Corcept Therapeutics Inc, Daiichi Sankyo Inc, Exact Sciences Corporation, Gilead Sciences Inc, Lilly, Mabwell Therapeutics Inc, Merck, Pfizer Inc, Summit Therapeutics; Contracted Research: Arvinas, AstraZeneca Pharmaceuticals LP, Corcept Therapeutics Inc, Genentech, a member of the Roche Group, Gilead Sciences Inc, Jazz Pharmaceuticals Inc, Mabwell Therapeutics Inc, Merck, Pfizer Inc, Relay Therapeutics.

Research To Practice CME Planning Committee Members, Staff and Reviewers
Planners, scientific staff and independent reviewers for Research To Practice have no relevant financial relationships to disclose.

Supporters
This activity is supported by educational grants from Agendia Inc, AstraZeneca Pharmaceuticals LP, Biotheranostics Inc, A Hologic Company, Exact Sciences Corporation, Genentech, a member of the Roche Group, and Merck.

San Antonio Marriott Rivercenter
101 Bowie St
San Antonio, TX 78205
Hotel Phone: (210) 223-1000

Meeting Room
To be announced.

Directions
The Marriott Rivercenter hotel is conveniently located within walking distance (1.5 blocks) of the Henry B González Convention Center, where the 2026 San Antonio Breast Cancer Symposium is taking place.

Program slides will be made available prior to the start of the session.

Registration to attend virtually is open to all professionals.

Please click the link to register for this live event directly on Zoom. Once you register, Zoom will send a confirmation email with your individual link to access the event. Please keep that confirmation email handy. If you do not receive it, contact our support team at meetings@researchtopractice.com.

To ensure seating and meal service, please check in at our onsite registration desk before the start of the meeting. We cannot guarantee seating after the start of the program.

Photography and/or video recording may be taken during the educational program by Research To Practice and used in future educational offerings.

Research To Practice fully complies with the legal requirements of the ADA. If you require any physical, dietary or other accommodations, please call us at (800) 233-6153 before the event.

If you have any questions, please feel free to contact us via email at Meetings@ResearchToPractice.com, or call (800) 233-6153.

Second Opinion: A Case-Based Exploration of Clinical Investigator Best Practices Related to the Management of Triple-Negative Breast Cancer

A CME Satellite Symposium

Program Schedule — Central Time
Wednesday, December 9, 2026
6:30 PM – 7:00 PM — Registration and Dinner Buffet
7:00 PM – 9:00 PM — Educational Meeting

Location
San Antonio Marriott Rivercenter
101 Bowie St
San Antonio, Texas
Hotel Phone: (210) 223-1000

Meeting Room
To be announced.

No registration fee. Preregistration is required for in-person attendance in San Antonio as seating is limited.

Professor Giuseppe Curigliano

Faculty

Professor Giuseppe Curigliano

MD, PhD

University of Milano, European Institute of Oncology, Milano, Italy

Clinical Director, Division of Early Drug Development for Innovative Therapy, Co-Chair, Cancer Experimental Therapeutics Program, Department of Oncology and Hemato-Oncology

Professor Peter Schmid

Faculty

Professor Peter Schmid

FRCP, MD, PhD

Barts Cancer Institute, London, United Kingdom

Lead, Centre of Experimental Cancer Medicine

Tiffany A Traina

Faculty

Tiffany A Traina

MD, FASCO

Memorial Sloan Kettering Cancer Center, New York, New York

Vice Chair, Department of Medicine, Section Head, Triple-Negative Breast Cancer Clinical Research Program, Associate Attending Physician, Breast Medicine Service

Weill Cornell Medical College, New York, New York

Associate Professor

Reshma L Mahtani

Moderator

Reshma L Mahtani

DO

Baptist Health Herbert Wertheim Cancer Institute, Miami, Florida

Chief of Breast Medical Oncology

This symposium is sponsored by Research To Practice and supported by grants from AstraZeneca Pharmaceuticals LP, Bristol Myers Squibb, and Daiichi Sankyo Inc. This is not an official program of the San Antonio Breast Cancer Symposium®.

Join us on Wednesday, December 9th from 7:00 PM to 9:00 PM central time (8:00 PM to 10:00 PM eastern time).

Module 1: Evolving Approach to First-Line Therapy for Metastatic Triple-Negative Breast Cancer (mTNBC)

  • Outcomes with historical standard treatments for PD-L1-negative and PD-L1-positive mTNBC; rationale for moving TROP2-directed antibody-drug conjugates (ADCs) earlier in the treatment sequence
  • Structural and mechanistic similarities and differences among the approved and investigational TROP2-directed ADCs, sacituzumab govitecan, datopotamab deruxtecan (Dato-DXd) and sacituzumab tirumotecan (sac-TMT); implications for efficacy and tolerability
  • Major efficacy and safety findings from the Phase III ASCENT-03 and TROPION-Breast02 trials comparing single-agent sacituzumab govitecan and Dato-DXd, respectively, to chemotherapy as first-line treatment for patients with mTNBC not eligible for immunotherapy; FDA approvals of both regimens and clinical implications
  • Published outcomes from the Phase III ASCENT-04/KEYNOTE-D19 study evaluating sacituzumab govitecan in combination with pembrolizumab for patients with previously untreated PD-L1-positive mTNBC
  • FDA approval of sacituzumab govitecan both as a monotherapy and in combination with pembrolizumab for the first-line treatment of mTNBC; optimal incorporation into clinical practice
  • Updated NCCN Guidelines supporting the use of sacituzumab govitecan, as monotherapy and combined with pembrolizumab, and Dato-DXd monotherapy as first-line therapy for mTNBC; current and future roles of these strategies
  • Ongoing Phase III TROPION-Breast05 and TroFuse-011 studies evaluating Dato-DXd and sac-TMT, respectively, in combination with anti-PD-1/PD-L1 antibodies as first-line therapy for mTNBC; estimated completion dates and clinical implications
  • Long-term data guiding the use of PARP inhibitors for patients with mTNBC and BRCA or other homologous recombination repair gene mutations; current application in the front-line setting

Module 2: Selection and Sequencing of Therapy for Relapsed/Refractory (R/R) mTNBC; Novel Agents and Strategies Under Investigation

  • Extended follow-up with and current role of sacituzumab govitecan for R/R mTNBC
  • Updated data with trastuzumab deruxtecan (T-DXd) in the subgroup of patients with previously treated hormone receptor-negative, HER2-low advanced breast cancer in the Phase III DESTINY-Breast04 study; current role as one of the available treatment options
  • Known mechanisms of resistance to available ADCs; current role of T-DXd after disease progression on sacituzumab govitecan or Dato-DXd and vice versa
  • Mechanism of antitumor activity and structural components of the EGFR x HER3 ADC izalontamab brengitecan (iza-bren)
  • Available efficacy and safety data with iza-bren for mTNBC, including from the Chinese Phase III PANKU-Breast02 study; ongoing investigation in the up-front setting in a global population in the Phase III IZABRIGHT-Breast01 trial
  • Mechanism of action of the PD-L1 x VEGF-A bispecific antibody pumitamig and rationale for its evaluation as treatment for advanced TNBC
  • Early efficacy and safety outcomes with pumitamig/chemotherapy as first- and second-line therapy for patients with mTNBC; ongoing Phase III ROSETTA Breast-01 trial for previously untreated PD-L1-negative disease
  • Other promising novel agents and strategies under investigation for patients with mTNBC

Module 3: Current and Future Management of Localized TNBC

  • Long-term data from the Phase III KEYNOTE-522 trial evaluating neoadjuvant pembrolizumab combined with chemotherapy and continued as a single agent after surgery for high-risk localized TNBC
  • Patient selection for and practical application of neoadjuvant and adjuvant pembrolizumab
  • Key efficacy and safety findings, including overall survival outcomes, among patients with TNBC from the Phase III OlympiA trial assessing adjuvant olaparib versus placebo for BRCA-mutant, high-risk, HER2-negative breast cancer
  • Current role of adjuvant olaparib for patients with TNBC and a germline BRCA1/2 mutation
  • Ongoing Phase III trials evaluating TROP2-targeted ADCs as a component of neoadjuvant or adjuvant therapy for localized TNBC: TROPION-Breast04, ASCENT-05, ADAPT-TN-III, ADAPT-TN-IV, TroFuse-012 and TroFuse-032; estimated completion dates

Module 4: Tolerability Considerations with ADCs for TNBC

  • Spectrum, incidence and severity of common and unique adverse events (AEs) with different ADCs used in the management of TNBC
  • Monitoring and management of acute “chemotherapy-like” AEs, such as cytopenias and gastrointestinal events, reported with ADCs
  • Recommended algorithms for mitigating more serious (eg, interstitial lung disease, left ventricular dysfunction) or unique (eg, oral mucositis/stomatitis, ocular AEs) toxicities documented with one or more ADCs
  • Effect on the tolerability profile of TROP2-targeted ADCs when they are combined with anti-PD-1/PD-L1 antibodies; strategies to determine the etiology of AEs that could be attributable to either agent
  • Implications of the tolerability profiles for selecting ADCs for patients with mTNBC

Target Audience
This activity is intended for medical oncologists, breast surgeons, radiation oncologists and other healthcare professionals involved in the diagnosis and treatment of breast cancer.

Learning Objectives
Upon completion of this activity, participants should be able to

  • Consider available research data evaluating anti-PD-1/PD-L1 antibody-based approaches for patients with localized triple-negative breast cancer (TNBC), and assess the role of these strategies in clinical practice.
  • Evaluate published research findings, patient preferences and clinical factors, such as PD-L1, HER2 and BRCA status, in the selection and sequencing of available therapeutic agents and strategies for patients with newly diagnosed metastatic TNBC (mTNBC).
  • Review published research data supporting antibody-drug conjugate (ADC) therapy in combination with anti-PD-1/PD-L1 antibodies for patients with mTNBC, and use this information to make appropriate treatment recommendations.
  • Assess recently presented clinical research findings with TROP2-directed ADC monotherapy as first-line treatment for mTNBC, and optimally incorporate these agents into patient care.
  • Understand the biological rationale for the evaluation of HER2-directed ADCs for HER2-low mTNBC, and identify patients appropriate for this treatment approach.
  • Recognize the spectrum, frequency and severity of treatment-emergent adverse events associated with agents and approaches commonly used in the management of TNBC, and develop strategies to monitor for, prevent and manage these complications.
  • Assess the mechanisms of action of, early data with and ongoing clinical trials evaluating other novel agents and treatment strategies under development for TNBC.

CE Credit
CME credit information will be given to each participant as part of the meeting course materials.

Accreditation Statement
Research To Practice is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation Statement
Research To Practice designates this live activity for a maximum of 2 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Privacy Policy
Personal information and data sharing: Research To Practice aggregates deidentified user data for program-use analysis, program development, activity planning and site improvement. We may provide aggregate and deidentified data to third parties, including commercial supporters. We do not share or sell personally identifiable information to any unaffiliated third parties or commercial supporters. Please see our privacy policy at ResearchToPractice.com/Privacy-Policy for more information.

Unlabeled/Unapproved Uses Notice
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the provider or grantors.

Content Validation and Disclosures
Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education and adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of an accredited continuing education activity, including faculty, planners, reviewers and others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant financial relationships will have been mitigated prior to the commencement of this activity. In addition, all activity content is reviewed by RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations. Faculty disclosures to be announced.

FACULTY — The following faculty reported relevant financial relationships with ineligible entities:

Prof Curigliano — Advisory Committees, Consulting Agreements and Speakers Bureaus: AstraZeneca Pharmaceuticals LP, Daiichi Sankyo Inc, Exact Sciences Corporation, Gilead Sciences Inc, Lilly, Menarini Group, Novartis, Pfizer Inc, Roche Laboratories Inc; Data and Safety Monitoring Boards/Committees: Lilly, Pfizer Inc, Roche Laboratories Inc. Prof Schmid — Consulting Agreements: AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Boehringer Ingelheim Pharmaceuticals Inc, Celgene Corporation, Eisai Inc, Merck, Novartis, Pfizer Inc, Puma Biotechnology Inc, Roche Laboratories Inc. Dr Traina — Advisory Committees and Consulting Agreements: Aktis Oncology, AstraZeneca Pharmaceuticals LP, BioNTech SE, Bristol Myers Squibb, Corcept Therapeutics Inc, Daiichi Sankyo Inc, Ellipses Pharma, Exact Sciences Corporation, Genentech, a member of the Roche Group, Gilead Sciences Inc, Merck, Pfizer Inc, Stemline Therapeutics Inc, Veracyte Inc; Contracted Research: Astellas, AstraZeneca Pharmaceuticals LP, BioNTech SE, Corcept Therapeutics Inc, Daiichi Sankyo Inc, Genentech, a member of the Roche Group, Pfizer Inc.

MODERATOR
Dr Mahtani — Consulting Agreements: Agendia Inc, Celcuity, Daiichi Sankyo Inc, Genentech, a member of the Roche Group, Gilead Sciences Inc, Hologic Inc, Lilly, Novartis, Pfizer Inc, Puma Biotechnology Inc, Stemline Therapeutics Inc; Contracted Research: Gilead Sciences Inc.

Research To Practice CME Planning Committee Members, Staff and Reviewers
Planners, scientific staff and independent reviewers for Research To Practice have no relevant financial relationships to disclose.

Supporters
This activity is supported by educational grants from AstraZeneca Pharmaceuticals LP, Bristol Myers Squibb, and Daiichi Sankyo Inc.

San Antonio Marriott Rivercenter
101 Bowie St
San Antonio, TX 78205
Hotel Phone: (210) 223-1000

Meeting Room
To be announced.

Directions
The Marriott Rivercenter hotel is conveniently located within walking distance (1.5 blocks) of the Henry B González Convention Center, where the 2026 San Antonio Breast Cancer Symposium is taking place.

Program slides will be made available prior to the start of the session.

Registration to attend virtually is open to all professionals.

Please click the link to register for this live event directly on Zoom. Once you register, Zoom will send a confirmation email with your individual link to access the event. Please keep that confirmation email handy. If you do not receive it, contact our support team at meetings@researchtopractice.com.

To ensure seating and meal service, please check in at our onsite registration desk before the start of the meeting. We cannot guarantee seating after the start of the program.

Photography and/or video recording may be taken during the educational program by Research To Practice and used in future educational offerings.

Research To Practice fully complies with the legal requirements of the ADA. If you require any physical, dietary or other accommodations, please call us at (800) 233-6153 before the event.

If you have any questions, please feel free to contact us via email at Meetings@ResearchToPractice.com, or call (800) 233-6153.

Second Opinion: A Case-Based Exploration of Clinical Investigator Best Practices Related to the Use of Oral SERDs for HR-Positive Breast Cancer

A CME Satellite Symposium

Program Schedule — Central Time
Thursday, December 10, 2026
6:30 PM – 7:00 PM — Registration and Dinner Buffet
7:00 PM – 9:00 PM — Educational Meeting

Location
San Antonio Marriott Rivercenter
101 Bowie St
San Antonio, Texas
Hotel Phone: (210) 223-1000

Meeting Room
To be announced.

No registration fee. Preregistration is required for in-person attendance in San Antonio as seating is limited.

Aditya Bardia

Faculty

Aditya Bardia

MD, MPH

UCLA Health Jonsson Comprehensive Cancer Center, Los Angeles, California

Program Director, Breast Medical Oncology, Assistant Chief (Translational Research), Division of Hematology-Oncology, Director of Translational Research Integration

Geffen School of Medicine, University of California Los Angeles, Los Angeles, California

Professor of Medicine

Erica Mayer

Faculty

Erica Mayer

MD, MPH, FASCO

Dana-Farber Cancer Institute, Boston, Massachusetts

Director of Breast Cancer Clinical Research, Breast Oncology Center

Harvard Medical School, Boston, Massachusetts

Associate Professor of Medicine

Joyce O’Shaughnessy

Faculty

Joyce O’Shaughnessy

MD

Baylor University Medical Center, Dallas, Texas

Celebrating Women Chair in Breast Cancer Research

Texas Oncology, Dallas, Texas

Director, Breast Cancer Research Program

Sarah Cannon Research Institute, Dallas, Texas

Seth Wander

Moderator

Seth Wander

MD, PhD

Massachusetts General Hospital, Boston, Massachusetts

Director of Precision Medicine, Termeer Center for Targeted Therapies, Director of Translational Research, Breast Oncology Program

Harvard Medical School, Boston, Massachusetts

Assistant Professor of Medicine

This symposium is sponsored by Research To Practice and supported by grants from AstraZeneca Pharmaceuticals LP, Genentech, a member of the Roche Group, and Stemline Therapeutics Inc. This is not an official program of the San Antonio Breast Cancer Symposium®.

Join us on Thursday, December 10th from 7:00 PM to 9:00 PM central time (8:00 PM to 10:00 PM eastern time).

Module 1: Current Role of Oral Selective Estrogen Receptor Degrader (SERD) Monotherapy in the Treatment of Hormone Receptor (HR)-Positive Metastatic Breast Cancer (mBC)

  • Key factors affecting the selection of therapy for patients with HR-positive, HER2-negative mBC progressing on treatment with a CDK4/6 inhibitor and endocrine therapy (ET)
  • Known mechanisms of resistance to ET in patients with HR-positive mBC; incidence of ESR1 mutations in endocrine-resistant mBC
  • Optimal methodology and timing of assessment for ESR1 mutations in patients with progressive HR-positive, HER2-negative mBC
  • Pharmacologic, structural and mechanistic similarities and differences between available (eg, elacestrant, imlunestrant) and investigational (eg, giredestrant, camizestrant) oral SERDs; implications for antitumor activity and tolerability
  • Available results from the pivotal Phase III EMERALD trial evaluating elacestrant for pretreated HR-positive, HER2-negative mBC
  • Updated efficacy results from the Phase III EMBER-3 study evaluating imlunestrant alone or in combination with abemaciclib for patients with pretreated HR-positive, HER2-negative mBC; recent FDA approval of the combination regimen and clinical implications
  • FDA approvals of elacestrant and imlunestrant for previously treated HR-positive, HER2-negative, ESR1-mutated mBC; optimal incorporation into management algorithms
  • Other available datasets and real-world analyses examining the role of oral SERD monotherapy in clinical management
  • Incidence, severity and optimal approaches to monitoring for and management of toxicities associated with oral SERD therapy

Module 2: Combination Approaches with Oral SERDs for HR-Positive Relapsed/Refractory mBC

  • Biological rationale for combining oral SERDs with other systemic therapies for HR-positive mBC
  • Efficacy and safety outcomes documented in the imlunestrant/abemaciclib arm of EMBER-3 among previously treated breast cancer with and without ESR1 mutations; recent FDA approval of and optimal candidates for this combination therapy
  • NCCN guideline inclusion of imlunestrant/abemaciclib and potential clinical role
  • Available findings from the Phase Ib/II ELEVATE trial evaluating elacestrant in combination with various therapeutic partners, such as abemaciclib, everolimus and capivasertib
  • Design, eligibility criteria and key efficacy and safety endpoints of the Phase III evERA study assessing giredestrant with everolimus versus standard ET with everolimus for pretreated, HR-positive, HER2-negative mBC
  • Demonstration of improved progression-free survival with giredestrant in combination with everolimus in the intention-to-treat and ESR1-mutated populations in the evERA study
  • Ongoing FDA review and potential role of giredestrant/everolimus in the management of ET-pretreated, HR-positive, HER2-negative mBC; optimal candidates for combination therapy
  • Spectrum, frequency and severity of side effects observed with various oral SERD-based combination regimens; optimal monitoring for and management of treatment-related adverse events (TRAEs)
  • Ongoing clinical trials evaluating other SERD-based combinations, such as the ADELA and EvoPAR-BR01 studies

Module 3: Available Evidence with Oral SERDs as a Component of First-Line Treatment

  • Conceptual rationale for early therapeutic switching for patients with molecular progression in the absence of clinical or radiographic progression
  • Key efficacy findings from the Phase III PADA-1 proof-of-concept trial evaluating a switch to fulvestrant and palbociclib versus no switch for patients with HR-positive, HER2-negative mBC found to harbor an ESR1 mutation during aromatase inhibitor (AI) and palbociclib therapy
  • Published findings from the Phase III SERENA-6 study evaluating a switch from an AI to camizestrant after detection of an emergent ESR1 mutation during first-line therapy for HR-positive, HER2-negative mBC; recent FDA approval and optimal incorporation into the treatment paradigm
  • Published findings from SERENA-6 with early therapeutic switching to camizestrant for patients with molecular progression; impact on patient-reported outcomes, including deterioration in global health status and quality of life and time to deterioration in pain
  • Design, eligibility criteria and emerging efficacy results from the Phase III persevERA trial evaluating giredestrant/palbociclib as first-line treatment
  • Other ongoing clinical trials evaluating oral SERDs in combination with CDK4/6 inhibitors as first-line treatment, such as the SERENA-4 and pionERA studies

Module 4: Potential Role of SERDs in the Localized Disease Setting

  • Rationale for the evaluation of oral SERDs as adjuvant therapy for localized HR-positive, HER2-negative breast cancer
  • Available findings from the Phase III lidERA Breast Cancer study evaluating adjuvant giredestrant versus physician’s choice of adjuvant endocrine monotherapy for patients with HR-positive, HER2-negative localized breast cancer
  • Improvement in invasive disease-free survival and other key efficacy outcomes documented with adjuvant giredestrant in the lidERA Breast Cancer study
  • Spectrum, frequency and severity of toxicities with giredestrant in the lidERA Breast Cancer study; comparative tolerability of giredestrant versus standard adjuvant ET
  • Potential clinical role of adjuvant giredestrant for patients with HR-positive, HER2-negative localized breast cancer; implications for treatment sequencing in the metastatic setting
  • Ongoing Phase III trials, such as ELEGANT, TREAT ctDNA, EMBER-4, CAMBRIA-1 and CAMBRIA-2, attempting to further define the optimal role of oral SERDs in the adjuvant setting; estimated completion dates

Target Audience
This activity is intended for medical oncologists, breast surgeons, radiation oncologists and other healthcare professionals involved in the diagnosis and treatment of breast cancer.

Learning Objectives
Upon completion of this activity, participants should be able to

  • Appreciate the incidence and clinical implications of ESR1 mutations for endocrine-resistant metastatic breast cancer (mBC) and determine optimal strategies to effectively identify patients harboring these abnormalities.
  • Understand the biological rationale for, mechanism of action of, and pharmacologic similarities and differences between available and investigational oral selective estrogen receptor degraders (SERDs).
  • Interrogate published research documenting the efficacy of oral SERD monotherapy for hormone receptor (HR)-positive, HER2-negative, ESR1-mutated mBC progressing on standard endocrine therapy in combination with a CDK4/6 inhibitor to optimally integrate these agents into the care of appropriately selected patients.
  • Review available research data evaluating the role of serial ESR1 testing using circulating tumor DNA as a means to identify molecular progression and inform early therapeutic switching for patients with HR-positive mBC receiving CDK4/6 inhibitor-based first-line therapy, and consider the potential role of this novel strategy.
  • Evaluate available clinical trial data with oral SERDs in combination with other systemic therapies, such as CDK4/6 inhibitors and PI3K/AKT/mTOR inhibitors, and consider the potential role of these regimens.
  • Appraise the scientific justification for, available data with and potential clinical role of oral SERDs as adjuvant treatment for patients with localized HR-positive, HER2-negative breast cancer.
  • Appreciate side effects associated with available and investigational oral SERDs alone and in combination with other therapies, and use this information to develop supportive management plans for patients undergoing treatment with these approaches.
  • Assess ongoing clinical research studies evaluating novel applications of oral SERDs for HR-positive breast cancer, and counsel patients regarding the potential benefits of trial participation.

CE Credit
CME credit information will be given to each participant as part of the meeting course materials.

Accreditation Statement
Research To Practice is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation Statement
Research To Practice designates this live activity for a maximum of 2 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Privacy Policy
Personal information and data sharing: Research To Practice aggregates deidentified user data for program-use analysis, program development, activity planning and site improvement. We may provide aggregate and deidentified data to third parties, including commercial supporters. We do not share or sell personally identifiable information to any unaffiliated third parties or commercial supporters. Please see our privacy policy at ResearchToPractice.com/Privacy-Policy for more information.

Unlabeled/Unapproved Uses Notice
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the provider or grantors.

Content Validation and Disclosures
Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education and adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of an accredited continuing education activity, including faculty, planners, reviewers and others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant financial relationships will have been mitigated prior to the commencement of this activity. In addition, all activity content is reviewed by RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

FACULTY — Dr Mayer has no relevant financial relationships to disclose. The following faculty reported relevant financial relationships with ineligible entities:

Dr Bardia — Consulting Agreements: Alyssum Therapeutics, AstraZeneca Pharmaceuticals LP, Daiichi Sankyo Inc, Genentech, a member of the Roche Group, Gilead Sciences Inc, Lilly, Menarini Group, Merck, Novartis, Pfizer Inc, Vyome; Contracted Research (Support to Institution): AstraZeneca Pharmaceuticals LP, Daiichi Sankyo Inc, Genentech, a member of the Roche Group, Gilead Sciences Inc, Lilly, Menarini Group, Merck, Novartis, OnKure Therapeutics, Pfizer Inc. Dr O’Shaughnessy — Advisory Committees and Consulting Agreements: Aadi Bioscience, Agendia Inc, Amgen Inc, Aptitude Health, AstraZeneca Pharmaceuticals LP, BioNTech SE, Bristol Myers Squibb, Daiichi Sankyo Inc, Duality Biologics, Eisai Inc, Ellipses Pharma, Exact Sciences Corporation, G1 Therapeutics Inc, Genentech, a member of the Roche Group, Gilead Sciences Inc, Guardant Health, HiberCell, Jazz Pharmaceuticals Inc, Johnson & Johnson, Lilly, Menarini Group, Merck, Mersana Therapeutics Inc, Natera Inc, Novartis, Pfizer Inc, Pierre Fabre, Puma Biotechnology Inc, RayzeBio, Roche Laboratories Inc, Sanofi, Seagen Inc, Stemline Therapeutics Inc, Summit Therapeutics, Tempus, TerSera Therapeutics LLC. Additional faculty to be announced.

MODERATOR
Dr Wander — Advisory Committees: AstraZeneca Pharmaceuticals LP, Celcuity, Genentech, a member of the Roche Group, Lilly, Menarini Group, Puma Biotechnology Inc, Regor Therapeutics, Stemline Therapeutics Inc; Consulting Agreements: 2nd.MD, Arvinas, Biovica International AB, Boundless Bio, Daiichi Sankyo Inc, Delcath Systems Inc, Foundation Medicine, Gilead Sciences Inc, Halda Therapeutics, Novartis, Pfizer Inc, Precede Biosciences, TerSera Therapeutics LLC, Veracyte Inc; Contracted Research: Arvinas, Boundless Bio, Genentech, a member of the Roche Group, Halda Therapeutics, Lilly, Menarini Group, Pfizer Inc, Phoenix Molecular Designs, Puma Biotechnology Inc, Regor Therapeutics, Sermonix Pharmaceuticals, Stemline Therapeutics Inc. 

Research To Practice CME Planning Committee Members, Staff and Reviewers
Planners, scientific staff and independent reviewers for Research To Practice have no relevant financial relationships to disclose.

Supporters
This activity is supported by educational grants from AstraZeneca Pharmaceuticals LP, Genentech, a member of the Roche Group, and Stemline Therapeutics Inc.

San Antonio Marriott Rivercenter
101 Bowie St
San Antonio, TX 78205
Hotel Phone: (210) 223-1000

Meeting Room
To be announced.

Directions
The Marriott Rivercenter hotel is conveniently located within walking distance (1.5 blocks) of the Henry B González Convention Center, where the 2026 San Antonio Breast Cancer Symposium is taking place.

Program slides will be made available prior to the start of the session.

Registration to attend virtually is open to all professionals.

Please click the link to register for this live event directly on Zoom. Once you register, Zoom will send a confirmation email with your individual link to access the event. Please keep that confirmation email handy. If you do not receive it, contact our support team at meetings@researchtopractice.com.

To ensure seating and meal service, please check in at our onsite registration desk before the start of the meeting. We cannot guarantee seating after the start of the program.

Photography and/or video recording may be taken during the educational program by Research To Practice and used in future educational offerings.

Research To Practice fully complies with the legal requirements of the ADA. If you require any physical, dietary or other accommodations, please call us at (800) 233-6153 before the event.

If you have any questions, please feel free to contact us via email at Meetings@ResearchToPractice.com, or call (800) 233-6153.

Second Opinion: A Case-Based Exploration of Clinical Investigator Best Practices Related to the Use of PI3K/AKT/mTOR Inhibitors for HR-Positive Breast Cancer

A CME Satellite Symposium

Program Schedule — Central Time
Tuesday, December 8, 2026
6:30 PM – 7:00 PM — Registration and Dinner Buffet
7:00 PM – 9:00 PM — Educational Meeting

Location
San Antonio Marriott Rivercenter
101 Bowie St
San Antonio, Texas
Hotel Phone: (210) 223-1000

Meeting Room
To be announced.

No registration fee. Preregistration is required for in-person attendance in San Antonio as seating is limited.

Sara A Hurvitz

Faculty

Sara A Hurvitz

MD, FACP

Fred Hutchinson Cancer Center, Seattle, Washington

Professor of Medicine, Smith Family Endowed Chair in Women’s Health, Senior Vice President, Clinical Research Division

UW Medicine, Seattle, Washington

Head, Division of Hematology/Oncology, Department of Medicine

Komal Jhaveri

Faculty

Komal Jhaveri

MD, FACP, FASCO

Memorial Sloan Kettering Cancer Center, New York, New York

Patricia and James Cayne Chair for Junior Faculty, Associate Attending Physician, Breast Medicine Service and Early Drug Development Service, Section Head, Endocrine Therapy Research Program

Weill Cornell College of Medicine, New York, New York

Associate Professor of Medicine

Nicholas Turner

Faculty

Nicholas Turner

MD, PhD

The Royal Marsden and ICR NIHR Biomedical Research Centre, London, United Kingdom

Director

The Royal Marsden NHS Foundation Trust

Director of Clinical Research

The Institute of Cancer Research, London, United Kingdom

Professor of Molecular Oncology, Director of Clinical Research

Hope S Rugo

Moderator

Hope S Rugo

MD

City of Hope Comprehensive Cancer Center, Duarte, California

Director, Women’s Cancers Program, Division Chief, Breast Medical Oncology, Professor, Department of Medical Oncology and Therapeutics Research

University of California, San Francisco

Professor Emeritus

This symposium is sponsored by Research To Practice and supported by grants from AstraZeneca Pharmaceuticals LP, Celcuity, and Genentech, a member of the Roche Group. This is not an official program of the San Antonio Breast Cancer Symposium®.

Join us on Tuesday, December 8th from 7:00 PM to 9:00 PM central time (8:00 PM to 10:00 PM eastern time).

Module 1: Identification and Management of Newly Diagnosed Hormone Receptor (HR)-Positive Metastatic Breast Cancer (mBC) Harboring a PIK3CA Mutation 

  • Optimal methodology and timing of testing to identify PI3K/AKT/PTEN alterations in patients with HR-positive, HER2-negative mBC 
  • Mechanistic similarities and differences between inavolisib and earlier-generation PI3K inhibitors such as alpelisib; implications for efficacy and tolerability 
  • Design, eligibility criteria and key efficacy findings, including overall survival outcomes, from the Phase III INAVO120 study evaluating inavolisib in combination with palbociclib and fulvestrant as first-line therapy for patients with endocrine-resistant, PIK3CA-mutant, HR-positive, HER2-negative mBC 
  • FDA approval of inavolisib/palbociclib/fulvestrant and current clinical role for newly diagnosed HR-positive, HER2-negative mBC with a PIK3CA mutation 
  • Ongoing Phase III trials (INAVO123, CAPItello-292, VIKTORIA-2) evaluating PI3K/AKT/mTOR inhibitors as a component of first-line therapy for patients with HR-positive, HER2-negative mBC; estimated completion dates 

Module 2: Current Management of Progressive HR-Positive mBC with a PI3K/AKT/PTEN Alteration 

  • Mechanism of action of the AKT inhibitor capivasertib; implications for target selectivity and antitumor activity compared to the PI3K inhibitors inavolisib and alpelisib 
  • Available efficacy findings, including final overall survival data, from the Phase III CAPItello-291 trial establishing the clinical benefit of capivasertib/fulvestrant for progressive HR-positive, HER2-negative mBC with PI3K/AKT/PTEN alterations 
  • FDA approval of capivasertib and current clinical role opposite other evidence-based options 
  • Mechanistic similarities and differences between the novel dual PI3K/mTOR inhibitor gedatolisib and currently approved PI3K/AKT/mTOR inhibitors; implications for antitumor activity and tolerability 
  • Design, eligibility criteria and primary and secondary endpoints of the Phase III VIKTORIA-1 trial evaluating gedatolisib in combination with fulvestrant with or without palbociclib for patients with HR-positive, HER2-negative advanced breast cancer whose disease progressed on or after prior CDK4/6 inhibitor therapy and an aromatase inhibitor; FDA approval and optimal incorporation into clinical practice 
  • Efficacy and safety findings from the PIK3CA-mutated cohort of VIKTORIA-1; anticipated full presentation of results and future role of gedatolisib-containing combination therapy 
  • Other Phase III efforts investigating promising novel agents and strategies for HR-positive mBC harboring PI3K/AKT/PTEN alterations 

Module 3: Optimal Approaches to the Management of Progressive PIK3CA Wild-Type, HR-Positive Disease 

  • Historical outcomes with standard second-line regimens for HR-positive, HER2-negative mBC with no actionable alterations 
  • Available data with and current role, if any, of CDK4/6 inhibitor continuation or rechallenge for patients with HR-positive, HER2-negative mBC progressing on first-line treatment with a CDK4/6 inhibitor and endocrine therapy 
  • Rationale for the evaluation of gedatolisib-containing regimens for PIK3CA wild-type, progressive, HR-positive, HER2-negative mBC; specific regimens evaluated in VIKTORIA-1 for this patient subset 
  • Recently published efficacy and safety findings from the PIK3CA wild-type cohort of VIKTORIA-1; comparative benefit of the triplet combination (gedatolisib with fulvestrant and palbociclib) and doublet combination (gedatolisib with fulvestrant) versus fulvestrant monotherapy 
  • FDA approval of gedatolisib-containing combination therapy for pretreated HR-positive, HER2-negative mBC that is PIK3CA wild-type 

Module 4: Tolerability Considerations with PI3K/AKT/mTOR Inhibitors 

  • Spectrum of common and agent-specific adverse events (AEs) documented with PI3K/AKT/mTOR inhibitors in mBC; comparative tolerability/toxicity profiles of the various agents 
  • Pathophysiology of hyperglycemia associated with PI3K/AKT/mTOR inhibitors; incidence, severity and timing of hyperglycemia with the various agents 
  • Optimal mitigation, monitoring and management protocols for PI3K/AKT/mTOR inhibitor-associated hyperglycemia 
  • Frequency and severity of GI and cutaneous toxicities with PI3K/AKT/mTOR inhibitors; strategies to prevent and ameliorate these AEs 
  • Impact on the tolerability of PI3K/AKT/mTOR inhibitors when administered in combination with endocrine therapy or CDK4/6 inhibitors; recommendations for monitoring and management of cytopenias with combination regimens 
  • Relative and absolute contraindications to the use of and other practical considerations with PI3K/AKT/mTOR inhibitors for mBC 

Target Audience
This activity is intended for medical oncologists, breast surgeons, radiation oncologists and other healthcare professionals involved in the diagnosis and treatment of breast cancer.

Learning Objectives
Upon completion of this activity, participants should be able to

  • Review available research findings documenting the correlation between the presence of various biomarkers (eg, PIK3CA/AKT1/PTEN alterations, ESR1 mutations) and response to specific therapies, and develop optimal testing algorithms for patients with hormone receptor (HR)-positive metastatic breast cancer (mBC). 
  • Recognize the frequency of PI3K/AKT/PTEN alterations in individuals with HR-positive mBC, and employ evidence-based approaches designed to target these aberrations for appropriate patients with newly diagnosed and relapsed/refractory disease. 
  • Understand the biological rationale for the development of agents targeting multiple components of the PI3K/AKT/mTOR pathway, and recognize available and emerging data with this strategy for patients with HR-positive, PIK3CA wild-type and PIK3CA-mutant mBC. 
  • Appreciate the clinical and biological factors that guide the selection and sequencing of therapy for HR-positive mBC, and use this information to personalize treatment recommendations. 
  • Recognize adverse events associated with available and investigational PI3K/AKT/mTOR inhibitors, and implement approaches to educate patients and manage complications. 
  • Evaluate available research findings with and ongoing studies evaluating novel PI3K/AKT/mTOR inhibitor-based approaches, and consider the future role of these strategies. 

CE Credit
CME credit information will be given to each participant as part of the meeting course materials.

Accreditation Statement
Research To Practice is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation Statement
Research To Practice designates this live activity for a maximum of 2 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Privacy Policy
Personal information and data sharing: Research To Practice aggregates deidentified user data for program-use analysis, program development, activity planning and site improvement. We may provide aggregate and deidentified data to third parties, including commercial supporters. We do not share or sell personally identifiable information to any unaffiliated third parties or commercial supporters. Please see our privacy policy at ResearchToPractice.com/Privacy-Policy for more information.

Unlabeled/Unapproved Uses Notice
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the provider or grantors.

Content Validation and Disclosures
Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education and adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of an accredited continuing education activity, including faculty, planners, reviewers and others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant financial relationships will have been mitigated prior to the commencement of this activity. In addition, all activity content is reviewed by RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations. Faculty disclosures to be announced.

FACULTY — The following faculty reported relevant financial relationships with ineligible entities:

Dr Hurvitz — Advisory Committees: Akari Therapeutics, BeOne, Boundless Bio, BriaCell, BridgeBio, Bristol Myers Squibb, Daiichi Sankyo Inc, Gilead Sciences Inc, Jazz Pharmaceuticals Inc, Lilly, Luminate, Mersana Therapeutics Inc, Novartis, Prelude Therapeutics, Roche Laboratories Inc; Consulting Agreements: ALX Oncology, Bayer HealthCare Pharmaceuticals, BeOne, Blueprint Medicines, Ellipses Pharma, EMBioSys, Genentech, a member of the Roche Group, Jazz Pharmaceuticals Inc, Myricx Bio; Contracted Research: AstraZeneca Pharmaceuticals LP, Daiichi Sankyo Inc, Menarini Group, Novartis, Stemline Therapeutics Inc; Data and Safety Monitoring Boards/Committees: Atossa Therapeutics (paid to institution), Roche Laboratories Inc (paid to UW); Nonrelevant Financial Relationships: Alliance for Clinical Trials in Oncology Foundation, InClin, Quantum Leap Healthcare Collaborative, ROMTech (Stocks for orthopedic device for postop pts; not cancer related). Dr Jhaveri — Advisory Committees and Consulting Agreements: Arvinas, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, BBOT, BeOne, Bicycle Therapeutics, Blueprint Medicines, ConcertAI, Daiichi Sankyo Inc, Eisai Inc, Genentech, a member of the Roche Group, Gilead Sciences Inc, Halda Therapeutics, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Menarini Group, Merck, Mersana Therapeutics Inc, Natera Inc, Novartis, Olema Oncology, Pfizer Inc, Precede Biosciences, RayzeBio, Regor Therapeutics, Relay Therapeutics, Scorpion Therapeutics, Stemline Therapeutics Inc, Zymeworks Inc; Contracted Research: AstraZeneca Pharmaceuticals LP, BBOT, Bicycle Therapeutics, Blueprint Medicines, Eisai Inc, Genentech, a member of the Roche Group, Gilead Sciences Inc, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Merck, Novartis, Pfizer Inc, Puma Biotechnology Inc, RayzeBio, Scorpion Therapeutics, Zymeworks Inc; Nonrelevant Financial Relationships: Breast Cancer Research Foundation, Fred’s Team, Manhasset Women’s Coalition Against Breast Cancer, National Cancer Institute (BRIMM/UG3 CA239861 Award). Prof Turner — Consultant/Advisory: AstraZeneca Pharmaceuticals LP, Exact Sciences Corporation, Genentech, a member of the Roche Group, GSK, Guardant Health, Inivata, Lilly, Novartis, Pfizer Inc, Repare Therapeutics; Research Funding: AstraZeneca Pharmaceuticals LP, Genentech, a member of the Roche Group, Guardant Health, Inivata, Invitae, Labcorp, MSD, Natera Inc, Personalis, Pfizer Inc. Additional faculty to be announced.

MODERATOR
Dr Rugo — Consulting Agreements: BioNTech SE, Bristol Myers Squibb, Helsinn Therapeutics (US) Inc, Napo Pharmaceuticals; Contracted Research — Funding to City of Hope: ALX Oncology, Bicycle Therapeutics, Genentech, a member of the Roche Group, Mabwell Therapeutics Inc, Merck, NiKang Therapeutics, Pfizer Inc, Phoenix Molecular Designs, Relay Therapeutics, Stemline Therapeutics Inc; Contracted Research — Funding to UCSF: Ambrx, AstraZeneca Pharmaceuticals LP, Daiichi Sankyo Inc, Genentech, a member of the Roche Group, Gilead Sciences Inc, Lilly, Merck, Novartis, Pfizer Inc, Stemline Therapeutics Inc. 

Research To Practice CME Planning Committee Members, Staff and Reviewers
Planners, scientific staff and independent reviewers for Research To Practice have no relevant financial relationships to disclose.

Supporters
This activity is supported by educational grants from AstraZeneca Pharmaceuticals LP, Celcuity, and Genentech, a member of the Roche Group.

San Antonio Marriott Rivercenter
101 Bowie St
San Antonio, TX 78205
Hotel Phone: (210) 223-1000

Meeting Room
To be announced.

Directions
The Marriott Rivercenter hotel is conveniently located within walking distance (1.5 blocks) of the Henry B González Convention Center, where the 2026 San Antonio Breast Cancer Symposium is taking place.

Program slides will be made available prior to the start of the session.

Registration to attend virtually is open to all professionals.

Please click the link to register for this live event directly on Zoom. Once you register, Zoom will send a confirmation email with your individual link to access the event. Please keep that confirmation email handy. If you do not receive it, contact our support team at meetings@researchtopractice.com.

To ensure seating and meal service, please check in at our onsite registration desk before the start of the meeting. We cannot guarantee seating after the start of the program.

Photography and/or video recording may be taken during the educational program by Research To Practice and used in future educational offerings.

Research To Practice fully complies with the legal requirements of the ADA. If you require any physical, dietary or other accommodations, please call us at (800) 233-6153 before the event.

If you have any questions, please feel free to contact us via email at Meetings@ResearchToPractice.com, or call (800) 233-6153.

Second Opinion: A Case-Based Exploration of Clinical Investigator Best Practices Related to the Management of HER2-Positive Breast Cancer

A CME Satellite Symposium

Program Schedule — Central Time
Tuesday, December 8, 2026
6:30 PM – 7:00 PM — Registration and Dinner Buffet
7:00 PM – 9:00 PM — Educational Meeting

Location
San Antonio Marriott Rivercenter
101 Bowie St
San Antonio, Texas
Hotel Phone: (210) 223-1000

Meeting Room
To be announced.

No registration fee. Preregistration is required for in-person attendance in San Antonio as seating is limited.

Nadia Harbeck

Faculty

Nadia Harbeck

MD, PhD

LMU University Hospital, Munich, Germany

Breast Center Director, Department of Obstetrics and Gynecology and Comprehensive Cancer Center Munich

Ian E Krop

Faculty

Ian E Krop

MD, PhD

Yale Cancer Center, New Haven, Connecticut

Professor of Medicine, Chief of Medical Oncology and Hematology

Sara M Tolaney

Moderator

Sara M Tolaney

MD, MPH

Dana-Farber Cancer Institute, Boston, Massachusetts

Chief, Division of Breast Oncology

Harvard Medical School, Boston, Massachusetts

Associate Professor of Medicine

Additional faculty to be announced.

This symposium is sponsored by Research To Practice and supported by grants from AstraZeneca Pharmaceuticals LP, Daiichi Sankyo Inc, and Puma Biotechnology Inc. This is not an official program of the San Antonio Breast Cancer Symposium®.

Join us on Tuesday, December 8th from 7:00 PM to 9:00 PM central time (8:00 PM to 10:00 PM eastern time).

Module 1: Evolving Care Paradigms for Patients with Localized HER2-Positive Breast Cancer 

  • Key clinical factors affecting the selection of neoadju­vant and adjuvant systemic therapy for patients with HER2-positive localized breast cancer; outcomes achieved with historical standards of care 
  • Published findings from the Phase III DESTINY-Breast11 study evaluating trastuzumab deruxtecan (T-DXd) as a component of neoadjuvant therapy for patients with high-risk, HER2-positive localized breast cancer 
  • Key data from the Phase III DESTINY-Breast05 study of T-DXd versus trastuzumab emtansine for high-risk, HER2-positive breast cancer in patients with residual invasive disease after neoadjuvant therapy 
  • FDA approvals of T-DXd in the neoadjuvant and adjuvant settings; current clinical role of T-DXd as a component of cura­tive-intent therapy 
  • Ongoing clinical research trials evaluating novel HER2-directed approaches for patients with localized HER2-positive breast cancer 

Module 2: Optimizing First-Line and Maintenance Therapy for HER2-Positive Metastatic Breast Cancer (mBC) 

  • Key factors affecting the selection of front-line and maintenance therapy for patients with HER2-positive mBC 
  • Published efficacy and safety findings from the Phase III DESTINY-Breast09 trial documenting the benefit of T-DXd in combination with pertuzumab versus taxane/trastuzumab/pertuzumab as first-line therapy for HER2-positive mBC 
  • FDA approval of T-DXd/pertuzumab as up-front therapy; optimal integration into practice 
  • Key efficacy and safety outcomes from the Phase III HER2CLIMB-05 study assessing tucatinib in combination with standard first-line maintenance therapy after chemotherapy-based induction for HER2-positive mBC 
  • Available data from the Phase III PATINA study evaluating the addition of palbociclib to mainte­nance HER2-targeted therapy and endocrine therapy after induction treatment for HR-positive, HER2-positive mBC 
  • Optimal selection of up-front maintenance therapy for patients with HR-negative and HR-positive, HER2-positive mBC, including those receiving first-line T-DXd/pertuzumab; ongoing trials (eg, DEMETHER) attempting to further guide this decision 

Module 3: Selection and Sequencing of Therapy for Relapsed/Refractory HER2-Positive mBC 

  • Outcomes documented among patients with previ­ously treated HER2-positive mBC in pivotal clini­cal research studies of T-DXd and tucatinib-based combinations 
  • Incidence of central nervous system metasta­ses in patients with HER2-positive mBC, and effect on overall prognosis 
  • Intracranial efficacy documented with T-DXd and tucatinib-based therapy in published research efforts 
  • Long-term findings with and optimal integra­tion of other evidence-based treatment options for patients with progressive HER2-positive mBC  
  • Other promising agents and strategies under inves­tigation for advanced HER2-positive breast cancer 

Module 4: Identification and Management of Adverse Events (AEs) with T-DXd and Other HER2-Targeted Strategies 

  • Spectrum, incidence and severity of common and unique AEs with different HER2-targeted ther­apies employed in the management of HER2- positive breast cancer 
  • Recommendations for monitoring and immediate reporting of symptoms of interstitial lung disease (ILD) and cardiac toxicities with T-DXd 
  • Strategies to manage T-DXd-associated ILD and cardiac toxicities; indications for restarting T-DXd after resolution of symptoms 
  • Recommended algorithms for monitoring for, mit­igating and managing cytopenias, gastrointestinal side effects and other complications of T-DXd and other HER2-targeted therapies 
  • Differences, if any, in the tolerability/toxicity profile of T-DXd in the (neo)adjuvant versus first-line met­astatic versus relapsed/refractory settings 

Target Audience
This activity is intended for medical oncologists, breast surgeons, radiation oncologists and other healthcare professionals involved in the diagnosis and treatment of breast cancer.

Learning Objectives
Upon completion of this activity, participants should be able to

  • Assess available Phase III data with HER2-directed antibody-drug conjugate (ADC) ther­apy as a component of neoadjuvant therapy for patients with high-risk localized disease, and consider the potential clinical role of this novel treatment approach. 
  • Evaluate current research evidence with HER2-directed ADC therapy for patients with HER2-positive localized breast cancer with residual disease after neoadjuvant treatment. 
  • Appraise available clinical research data, current guideline recommendations and expert best prac­tices to guide the selection of first-line and maintenance therapy for patients with newly diagnosed HER2-positive metastatic breast cancer (mBC). 
  • Review presented Phase III data with HER2-directed ADC therapy as a compo­nent of first-line and maintenance therapy, and consider the current role of this strategy for HER2-positive mBC. 
  • Recognize available research findings with HER2-targeted tyrosine kinase inhibitors as a component of maintenance therapy, and reflect on the potential utility of this approach for patients with HER2-positive mBC.  
  • Design an optimal approach to the care of patients with HER2-positive breast cancer and central nervous system metastases, evaluating the implications of prior treatment exposure, symptomatology, extent of and time to new onset of disease and other factors. 
  • Implement a plan of care to recognize and manage toxicities associated with agents and regimens commonly employed in the care of patients with HER2-positive breast cancer. 
  • Consider ongoing clinical research studies evaluating novel agents and treatment strategies under development for HER2-positive breast cancer, and counsel patients regarding the potential benefits of trial participation. 

CE Credit
CME credit information will be given to each participant as part of the meeting course materials.

Accreditation Statement
Research To Practice is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation Statement
Research To Practice designates this live activity for a maximum of 2 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Privacy Policy
Personal information and data sharing: Research To Practice aggregates deidentified user data for program-use analysis, program development, activity planning and site improvement. We may provide aggregate and deidentified data to third parties, including commercial supporters. We do not share or sell personally identifiable information to any unaffiliated third parties or commercial supporters. Please see our privacy policy at ResearchToPractice.com/Privacy-Policy for more information.

Unlabeled/Unapproved Uses Notice
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the provider or grantors.

Content Validation and Disclosures
Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education and adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of an accredited continuing education activity, including faculty, planners, reviewers and others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant financial relationships will have been mitigated prior to the commencement of this activity. In addition, all activity content is reviewed by RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations. Faculty disclosures to be announced.

FACULTY — The following faculty reported relevant financial relationships with ineligible entities:

Prof Harbeck — Consulting Agreements: Bayer HealthCare Pharmaceuticals, Exact Sciences Corporation, Pfizer Inc; Contracted Research (All to Institution): AstraZeneca Pharmaceuticals LP, Gilead Sciences Inc, Lilly, Menarini Group, MSD, Roche Laboratories Inc, Stemline Therapeutics Inc; Data and Safety Monitoring Boards/Committees: Gilead Sciences Inc, IQVIA; Speakers Bureaus: AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Daiichi Sankyo Inc, Gilead Sciences Inc, Lilly, Medscape, Menarini Group, MSD, Novartis, Pfizer Inc, Pierre Fabre, Roche Laboratories Inc, Stemline Therapeutics Inc, Viatris, Zuellig Pharma; Nonrelevant Financial Relationships: High5MD, Springer, WSG (Women’s Cancer Study Group) — minority ownership. Dr Krop — Advisory Committees: AstraZeneca Pharmaceuticals LP, Daiichi Sankyo Inc, Genentech, a member of the Roche Group, Gilead Sciences Inc, Merck KGaA, Puma Biotechnology Inc, Stemline Therapeutics Inc, Zentalis Pharmaceuticals; Consulting Agreements: AstraZeneca Pharmaceuticals LP. Additional faculty to be announced.

MODERATOR
Dr Tolaney — Advisory Committees: Valanx Biotech Gmbh; Consulting Agreements: Aktis Oncology, Ambrx Inc, Artios Pharma Limited, Arvinas, AstraZeneca Pharmaceuticals LP , Avenzo Therapeutics, Bayer HealthCare Pharmaceuticals, BeOne, Bicycle Therapeutics, BioNTech SE, Boehringer Ingelheim Pharmaceuticals Inc, Boundless Bio, Bristol Myers Squibb, Celcuity, Circle Pharma, Corcept Therapeutics Inc, Cullinan Therapeutics, Daiichi Sankyo Inc, Denali Therapeutics,Ellipses Pharma, Genentech, a member of the Roche Group, Gilead Sciences Inc, Jazz Pharmaceuticals Inc, Johnson & Johnson, Launch Therapeutics, Lilly, Menarini Group, Merck, Mersana Therapeutics Inc, Novartis, Olema Oncology, Ottimo Pharma, Pfizer Inc, Relay Therapeutics, Reveal Genomics, Samsung Bioepis, Seagen Inc, Stemline Therapeutics Inc, Summit Therapeutics, SystImmune Inc, Tempus, Veracyte Inc, Zuellig Pharma; Contracted Research (to Institution): AstraZeneca Pharmaceuticals LP, Bristol Myers Squibb, Daiichi Sankyo Inc, Exelixis Inc, Genentech, a member of the Roche Group, Gilead Sciences Inc, Jazz Pharmaceuticals Inc, Lilly, Menarini Group, Merck, NanoString Technologies, Novartis, Olema Oncology, OncoPep, Pfizer Inc, Seagen Inc, Stemline Therapeutics Inc; Travel Support: AstraZeneca Pharmaceuticals LP, Gilead Sciences Inc, Lilly, Pfizer Inc, Roche Laboratories Inc.

Research To Practice CME Planning Committee Members, Staff and Reviewers
Planners, scientific staff and independent reviewers for Research To Practice have no relevant financial relationships to disclose.

Supporters
This activity is supported by educational grants from AstraZeneca Pharmaceuticals LP, Daiichi Sankyo Inc, and Puma Biotechnology Inc.

San Antonio Marriott Rivercenter
101 Bowie St
San Antonio, TX 78205
Hotel Phone: (210) 223-1000

Meeting Room
To be announced.

Directions
The Marriott Rivercenter hotel is conveniently located within walking distance (1.5 blocks) of the Henry B González Convention Center, where the 2026 San Antonio Breast Cancer Symposium is taking place.

Program slides will be made available prior to the start of the session.

Registration to attend virtually is open to all professionals.

Please click the link to register for this live event directly on Zoom. Once you register, Zoom will send a confirmation email with your individual link to access the event. Please keep that confirmation email handy. If you do not receive it, contact our support team at meetings@researchtopractice.com.

To ensure seating and meal service, please check in at our onsite registration desk before the start of the meeting. We cannot guarantee seating after the start of the program.

Photography and/or video recording may be taken during the educational program by Research To Practice and used in future educational offerings.

Research To Practice fully complies with the legal requirements of the ADA. If you require any physical, dietary or other accommodations, please call us at (800) 233-6153 before the event.

If you have any questions, please feel free to contact us via email at Meetings@ResearchToPractice.com, or call (800) 233-6153.