TARGET AUDIENCE
This activity is intended for medical oncologists, hematology-oncology fellows and other healthcare providers involved in the treatment of lung cancer.

LEARNING OBJECTIVES

• Evaluate available and emerging data documenting the efficacy and safety of anti-PD-1/PD-L1 antibody-based approaches as neoadjuvant, adjuvant or consolidation therapy for patients with nonmetastatic non-small cell lung cancer (NSCLC).
• Acknowledge the FDA approval of adjuvant EGFR tyrosine kinase inhibitor therapy for early-stage NSCLC with an EGFR mutation, and identify patients for whom treatment with this approach would be warranted.
• Review published data documenting the efficacy of EGFR tyrosine kinase inhibitors for metastatic NSCLC with an EGFR tumor mutation, and apply this information in the care of appropriately selected patients.
• Assess the efficacy and safety of commercially available ALK inhibitors for patients with metastatic NSCLC with an ALK rearrangement, and use this information in selecting first- and later-line therapy.
• Consider recent therapeutic advances related to the use of anti-PD-1/PD-L1 antibodies as monotherapy or in combination with other systemic therapies for metastatic NSCLC, and discern how these approaches can be employed in the management of this disease.
• Develop a long-term care plan for patients with progressive NSCLC, considering prior systemic therapy, performance status and personal goals of treatment.
• Design an optimal approach to the long-term clinical care of patients with small cell lung cancer, considering available research and the implications of age, symptomatology and other factors.
• Reflect on agents and strategies currently under investigation for lung cancer, and appropriately refer eligible patients for clinical trial participation.

ACCREDITATION STATEMENT
Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

CREDIT DESIGNATION STATEMENT
Audio Program: Research To Practice designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Video Program: Research To Practice designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Video Lecture: Research To Practice designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

AMERICAN BOARD OF INTERNAL MEDICINE (ABIM) — MAINTENANCE OF CERTIFICATION (MOC)
Successful completion of these CME activities, which includes participation in the evaluation components and short post-tests, enables the participant to earn up to 1 (audio), 0.75 (video) and 1 (lecture) Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for each activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Please note, these programs have been specifically designed for the following ABIM specialty: medical oncology.

PRIVACY POLICY
Personal information and data sharing: Research To Practice aggregates deidentified user data for program-use analysis, program development, activity planning and site improvement. We may provide aggregate and deidentified data to third parties, including commercial supporters. We do not share or sell personally identifiable information to any unaffiliated third parties or commercial supporters. Please see our privacy policy at ResearchToPractice.com/Privacy-Policy for more information.

HOW TO USE THIS CME ACTIVITY
To receive credit for an activity in this series, the participant should review the CME information, listen to or view the MP3s, review the downloadable slide set, complete the post-test with a score of 80% and fill out the Educational Assessment and Credit Form. Program location URLs are noted below:

Audio Interview:
ResearchToPractice.com/OncologyTodayPostASCO23/Lung and Educational Assessment and Credit Form ResearchToPractice.com/OncologyTodayPostASCO23/Lung/CME.

Video Interview:
ResearchToPractice.com/OncologyTodayPostASCO23/Lung/Video and Educational Assessment and Credit Form ResearchToPractice.com/OncologyTodayPostASCO23/Lung/Video/CME.

Faculty Lecture:
ResearchToPractice.com/OncologyTodayPostASCO23/Lung/Presentation and Educational Assessment and Credit Form ResearchToPractice.com/OncologyTodayPostASCO23/Lung/Presentation/CME.

CONTENT VALIDATION AND DISCLOSURES
Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education and adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of an accredited continuing education activity, including faculty, planners, reviewers and others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of these activities. In addition, all activity content is reviewed by RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

FACULTY — The following faculty reported relevant financial relationships with ineligible entities:

Matthew Gubens, MD, MS
Professor of Medicine
Medical Director, Thoracic Medical Oncology
University of California, San Francisco
San Francisco, California

Advisory Committee: AnHeart Therapeutics, AstraZeneca Pharmaceuticals LP, Atreca, Cardinal Health, Genentech, a member of the Roche Group, Genzyme Corporation, Gilead Sciences Inc, Guardant Health, Invitae, iTeos Therapeutics, Merus BV, Sanofi, Summit Therapeutics, Surface Oncology; Contracted Research (Funding to Institution as Site PI): Amgen Inc, Celgene Corporation, Johnson & Johnson Pharmaceuticals, Merck, Novartis, OncoMed Pharmaceuticals Inc, Trizell.

RESEARCH TO PRACTICE MODERATOR, CME PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS — Planners, moderator, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.

These educational activities contain discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.

These activities are supported by educational grants from AstraZeneca Pharmaceuticals LP, Boehringer Ingelheim Pharmaceuticals, Inc, Daiichi Sankyo Inc, and Novocure Inc.

Release date: August 2023
Expiration date: August 2024

After completing the post-test, learners may download and review the answers here in order to identify further areas of study.