TARGET AUDIENCE
This activity is intended for medical oncologists, hematologists, surgeons, radiation oncologists and other healthcare professionals involved in basic, translational and clinical cancer research or treatment.

OVERVIEW OF ACTIVITY
Over the past 2 decades, the oncology community has witnessed a significant transformation in the way clinicians think about and approach the diagnosis and treatment of a variety of solid tumors. A multitude of specific diseases are now classified by the presence or absence of various genomic alterations or biomarker expression profiles and are managed differently based on this information. Given that one cancer may share a number of biologic similarities with another and that abnormalities found in one disease may be present in others, it is not surprising that an attempt is under way to apply knowledge and therapeutic understanding across multiple diseases. This rational approach to clinical research has yielded a growing body of evidence that a single “targeted” therapy can provide demonstrable benefit for patients with the same identified genetic abnormality regardless of the primary cancer type. One of the most compelling and recent examples of this phenomenon has been the documentation of efficacy and the subsequent FDA approval of PARP inhibitors for both breast and ovarian cancer. Researchers are also attempting to document the therapeutic potential of these agents in pancreatic and prostate cancer.

These proceedings from a satellite symposium held during the 2019 AACR Annual Meeting feature discussions with leading investigators about the role of PARP inhibition as a therapeutic strategy for ovarian, breast, prostate and pancreatic cancer. By providing information on important developments, this activity will assist medical oncologists and other healthcare professionals in addressing existing management uncertainties and determining the clinical role of PARP inhibition in these diseases.

LEARNING OBJECTIVES

• Appraise available guideline recommendations and investigator perspectives regarding genetic testing in ovarian, breast and prostate cancer, and use the results of these assessments to guide long-term treatment planning.
• Describe the rationale for testing patients with prostate cancer or pancreatic adenocarcinoma for mutations in DNA repair genes, and assess the possible clinical role of PARP inhibitors in the care of these patients.
• Evaluate available research data and investigator perspectives on the role of FDA-approved PARP inhibitors for patients with ovarian cancer, and safely integrate these agents into routine clinical care.
• Evaluate the FDA approvals of olaparib and talazoparib for patients with metastatic breast cancer and a germline BRCA mutation, and discern how these agents can be appropriately and safely integrated into routine clinical practice.

ACCREDITATION STATEMENT
Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

CREDIT DESIGNATION STATEMENT
CME credit is no longer available for this issue

AMERICAN BOARD OF INTERNAL MEDICINE (ABIM) — MAINTENANCE OF CERTIFICATION (MOC)
CME credit is no longer available for this issue

HOW TO USE THIS CME ACTIVITY
This CME activity consists of an audio component.
CME credit is no longer available for this issue

CONTENT VALIDATION AND DISCLOSURES
Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess conflicts of interest with faculty, planners and managers of CME activities. Conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

FACULTY — The following faculty (and their spouses/partners) reported relevant conflicts of interest, which have been resolved through a conflict of interest resolution process:

Emmanuel S Antonarakis, MD
Associate Professor of Oncology and Urology
Johns Hopkins University
The Sidney Kimmel Comprehensive Cancer Center
Baltimore, Maryland

Advisory Committee and Consulting Agreements: Amgen Inc, Astellas Pharma Global Development Inc, AstraZeneca Pharmaceuticals LP, Clovis Oncology, Dendreon Pharmaceuticals Inc, ESSA Pharma Inc, Janssen Biotech Inc, Medivation Inc, a Pfizer Company, Merck, Sanofi Genzyme; Contracted Research: AstraZeneca Pharmaceuticals LP, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, Dendreon Pharmaceuticals Inc, Genentech, Janssen Biotech Inc, Johnson & Johnson Pharmaceuticals, Merck, Novartis, Sanofi Genzyme, Tokai Pharmaceuticals Inc; Other Remunerated Activities: Co-inventor of a biomarker licensed to QIAGEN.

Kathleen Moore, MD
Jim and Christy Everest Endowed Chair in Cancer Research
Associate Director, Clinical Research
Director, Oklahoma TSET Phase I Program
Stephenson Cancer Center
Associate Professor, Section of Gynecologic Oncology
Director, Gynecologic Oncology Fellowship
Department of Obstetrics and Gynecology
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma

Advisory Committee: Aravive Inc, AstraZeneca Pharmaceuticals LP, Clovis Oncology, Genentech, ImmunoGen Inc, Janssen Biotech Inc, Merck, OncoMed Pharmaceuticals Inc, Pfizer Inc, Roche Laboratories Inc, Samumed, Tesaro, VBL Therapeutics; Contracted Research: Clovis Oncology, Genentech, Merck, PTC Therapeutics, Roche Laboratories Inc.

Michael J Pishvaian, MD, PhD
Phase I Program Director
Medical Director of the CRMO
Associate Professor
Lombardi Comprehensive Cancer Center
Washington, DC

Consulting Agreements: AstraZeneca Pharmaceuticals LP, Caris Life Sciences, Celgene Corporation, Merrimack Pharmaceuticals Inc, Perthera Inc, RenovoRx; Contracted Research: ARMO Biosciences, Bavarian Nordic, Bayer HealthCare Pharmaceuticals, Bristol-Myers Squibb Company, Calithera Biosciences, Celgene Corporation, Celldex Therapeutics, Curegenix Inc, FibroGen, Genentech, Gilead Sciences Inc, GlaxoSmithKline, Halozyme Inc, Incyte Corporation, Karyopharm Therapeutics, Lilly, MedImmune Inc, Merck, Novartis, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Regeneron Pharmaceuticals Inc, Tesaro; Ownership Interest: Perthera Inc; Paid Travel: AstraZeneca Pharmaceuticals LP, Caris Life Sciences, Perthera Inc, Sirtex Medical Ltd; Speakers Bureau: Sirtex Medical Ltd.

Melinda Telli, MD
Associate Professor of Medicine
Stanford University School of Medicine
Leader, Breast Oncology Clinical Research Group
Stanford Cancer Institute
Stanford, California

Advisory Committee: Aduro Biotech, Celgene Corporation, Genentech, Immunomedics Inc, Merck; Consulting Agreement: Pfizer Inc; Contracted Research: Biothera Pharmaceuticals Inc, Calithera Biosciences, EMD Serono Inc, Genentech, OncoSec Medical, Pfizer Inc, PharmaMar, Tesaro; Data and Safety Monitoring Board: G1 Therapeutics.

MODERATOR — Dr Love is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop CME activities from the following commercial interests: AbbVie Inc, Acerta Pharma — A member of the AstraZeneca Group, Adaptive Biotechnologies, Agendia Inc, Agios Pharmaceuticals Inc, Amgen Inc, Ariad Pharmaceuticals Inc, Array BioPharma Inc, Astellas Pharma Global Development Inc, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Biodesix Inc, bioTheranostics Inc, Boehringer Ingelheim Pharmaceuticals Inc, Boston Biomedical Inc, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, Daiichi Sankyo Inc, Dendreon Pharmaceuticals Inc, Eisai Inc, Exelixis Inc, Foundation Medicine, Genentech, Genmab, Genomic Health Inc, Gilead Sciences Inc, Guardant Health, Halozyme Inc, ImmunoGen Inc, Incyte Corporation, Infinity Pharmaceuticals Inc, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Jazz Pharmaceuticals Inc, Kite Pharma Inc, Lexicon Pharmaceuticals Inc, Lilly, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Merck, Merrimack Pharmaceuticals Inc, Myriad Genetic Laboratories Inc, Natera Inc, Novartis, Oncopeptides, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Prometheus Laboratories Inc, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Sandoz Inc, a Novartis Division, Sanofi Genzyme, Seattle Genetics, Sirtex Medical Ltd, Spectrum Pharmaceuticals Inc, Taiho Oncology Inc, Takeda Oncology, Tesaro, Teva Oncology, Tokai Pharmaceuticals Inc and Tolero Pharmaceuticals.

RESEARCH TO PRACTICE CME PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS — Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.

This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantor.

This activity is supported by an educational grant from AstraZeneca Pharmaceuticals LP.

Hardware/Software Requirements:
A high-speed Internet connection
A monitor set to 1280 x 1024 pixels or more
Internet Explorer 11 or later, Firefox 56 or later, Chrome 61 or later, Safari 11 or later, Opera 48 or later
Adobe Flash Player 27 plug-in or later
Adobe Acrobat Reader
(Optional) Sound card and speakers for audio

Release date: June 2019
Expiration date: June 2020